What is the difference between medetomidine and detomidine?

Medetomidine, dexmedetomidine, and detomidine are more specific for the alpha2 receptor than xylazine. Dexmedetomidine has twice the potency of medetomidine. Therefore these drugs should not be used interchangeably without consulting the dose recommendations.

How many mg mL is Dexdomitor?

Each mL of DEXDOMITOR contains 0.5 mg dexmedetomidine hydrochloride, 1.6 mg methylparaben (NF), 0.2 mg propylparaben (NF), 9.0 mg sodium chloride (USP), and water for injection (USP), q.s. INDICATIONS: DEXDOMITOR is indicated for use as a sedative and analgesic in dogs and cats to facili- tate clinical examinations.

What is detomidine used for?

Detomidine is an alpha-2 adrenoceptor agonist drug, which is used in veterinary medicine for sedation of large animals. It is highly potent and has sedative and analgesic properties.

How is detomidine administered?

Detomidine in the gel form (Dormosedan Gel) for horses is administered orally to produce mucosal absorption. It is indicated for producing minor standing sedation to facilitate minor procedures (shoeing, clipping, trimming) or calming a fractious horse. Onset of action is 40 minutes, and duration is 90–180 minutes.

What drug class is Detomidine?

Detomidine is an α2-adrenergic agonist that is used as a horse sedative. Normally, it is administered in the salt form, detomidine hydrochloride. This drug is prescribed by veterinarians and is marketed as Dormosedan.

How long does Detomidine last in horses?

Detomidine is another alpha-2 agent and lasts much longer. It also provides a better balanced stance so sometimes we use it instead of the xylazine/butorphanol combination for hind end work. Detomidine can last 30-60 minutes.

What is the concentration of Dexdomitor?

DEXDOMITOR® INJECTABLE SOLUTION Each mL of Dexdomitor Sterile Injectable Solution contains 0.5 mg dexmedetomidine hydrochloride, 1.6 mg methyl parahydroxybenzoate and 0.2 mg propyl parahydroxybenzoate as preservatives, 9.0 mg sodium chloride and water for injection.

How long does it take for Dexdomitor to wear off?

The peak sedative and analgesic effects are reached within 30 minutes after administration. Sedation lasts for at least 120 minutes post administration and analgesia lasts for at least 90 minutes. Spontaneous recovery occurs within 3 hours.

Is Detomidine a controlled substance?

“Detomidine hydrochloride is not a controlled substance like butor- phanol tartrate used in combination with other molecules,” said Dr. Donecker. “By using Dormosedan as a simple, one-sedative variable the veterinarian has more control over the level of sedation and analgesia.

How quickly does Dormosedan work?

The gel needs about 40 minutes to take effect and the sedation will last for about 90-180 minutes.

What is the generic name for Dexdomitor?

Dexmedetomidine

Clinical data
Trade names	Precedex, Dexdor, Igalmi, others
AHFS/Drugs.com	Monograph
License data	EU EMA: by INN US DailyMed: Dexmedetomidine
Pregnancy category	AU : B1

Can you give atropine with Dexdomitor?

Conclusions. The positive chronotropic effects of atropine might be attenuated with the use of dexmedetomidine or propofol during spinal anaesthesia. Although atropine may be administered when bradycardia occurs, a dose of atropine might result in an insufficient effect against the bradycardia.

What is the reversal for dexmedetomidine?

ANTISEDAN (atipamezole) is indicated for the reversal of the sedative and analgesic effects of DEXDOMITOR ® (dexmedetomidine hydrochloride) and DEXDOMITOR ® 0.1 (dexmedetomidine hydrochloride).

What is Detomidine HCL?

What is Detomidine Hydrochloride? Detomidine Hydrochloride is indicated for use as a sedative and analgesic to facilitate minor surgical and diagnostic procedures in mature horses and yearlings.

Can a horse overdose on Dormosedan?

Overdose of a sedative is rarely fatal in a healthy horse, but it can still be dangerous, especially if there is any underlying illness that makes them less good at maintaining their blood pressure.

Is Dexdomitor reversible?

RAPIDLY REVERSES THE SEDATIVE AND ANALGESIC EFFECTS OF DEXDOMITOR IN DOGS. ANTISEDAN (atipamezole) is indicated for the reversal of the sedative and analgesic effects of DEXDOMITOR ® (dexmedetomidine hydrochloride) and DEXDOMITOR ® 0.1 (dexmedetomidine hydrochloride).

Does Dexdomitor cause vasodilation?

Side effects of dexmedetomidine are mainly restricted to hemodynamic alterations. These include hypertension, bradycardia, and hypotension owing to pre- and postsynaptic α2-receptor activation, which causes vasoconstriction, vasodilatation, and reflex bradycardia [8, 9].

What is the reversal agent for dexmedetomidine?

Atipamezole is a non-selective α2 adrenoceptor antagonist. It rapidly reverses sedation/analgesia induced by dexmedetomidine.

How long does it take for precedex to wear off?

The terminal elimination half-life of intravenous dexmedetomidine ranged 2.1 to 3.1 hours in healthy adults and 2.2 to 3.7 hours in ICU patients.

How many milligrams of dexmedetomidine do you give a horse?

Methods: Thirty horses each were sedated with dexmedetomidine 3.5 μg kg-1(group DEX) or medetomidine 7 μg kg-1(group MED) intravenously.

What are the effects of dexmedetomidine on cats?

It was concluded that anaesthetic effects of medetomidine in cats are probably due entirely to its d-isomer and that dexmedetomidine at 25, 50 and 75 microg/kg induces dose-dependent sedation, analgesia and muscular relaxation of clinical significance in cats. Analgesics, Non-Narcotic / administration & dosage

Does dexmedetomidine affect cardiopulmonary function in horses administered with isoflurane?

Conclusions and clinical relevance: Horses administered dexmedetomidine required more than 50% of the medetomidine dose to reach equivalent sedation. During isoflurane anaesthesia, cardiopulmonary function was comparable between the two groups.

Is dexmedetomidine safe for dogs with propofol?

Dexmedetomidine is at least as safe and effective as medetomidine for use as a premedicant in dogs undergoing propofol-isoflurane anesthesia. Dexmedetomidine is at least as safe and effective as medetomidine for use as a premedicant in dogs undergoing propofol-isoflurane anesthesia.