What is meant by testicular feminization?

Androgen insensitivity (testicular feminization) syndrome is a rare inherited form of male pseudohermaphroditism that occurs in phenotypically normal women with adequate breast development, normal external genitalia, a vagina of variable depth, absent uterus, and sparse or absent pubic hair and axillary hair.

What is the opposite of testicular feminization?

Androgen insensitivity syndrome (AIS) is a Disorder of sex development involving hormonal resistance due to androgen receptor dysfunction. AIS results when the function of the androgen receptor (AR) is impaired.

Who has testicular feminization syndrome?

Testicular feminization syndrome: Now more appropriately called the complete androgen insensitivity syndrome, this is a genetic disorder that makes XY fetuses insensitive (unresponsive) to androgens (male hormones). Instead, they are born looking externally like normal girls.

How is testicular feminization syndrome treated?

Complete androgen insensitivity syndrome is treated with estrogen replacement therapy after puberty. Undescended testicles will be surgically removed because of the risk that they will become cancerous. Treatment for partial androgen insensitivity syndrome may include corrective surgery to match gender identity.

What causes testicular feminization?

Abstract. Introduction and objectives: Testicular feminization is the syndrome when a male, genetically XY, because of various abnormalities of the X chromosome, is resistant to the actions of the androgen hormones, which in turn stops the forming of the male genitalia and gives a female phenotype.

What is reifenstein syndrome?

Reifenstein syndrome is a term comprising a heterogeneous group of androgen deficiency syndromes due to X-linked recessive androgen receptor defect in 46, XY men with normal androgen secretion. Females are clinically not affected.

What do people with AIS look like?

A person with complete AIS appears to be female but has no uterus. They have very little armpit and pubic hair. At puberty, female sex characteristics (such as breasts) develop. However, the person does not menstruate and become fertile.

Do XXY have periods?

Mostly, it depends on the sexual and reproductive organs an individual is born with, whether they will have periods or not. If an intersex person is born with a functioning uterus, ovaries, and a vagina, most likely that person will start menstruating at puberty.

Can someone with AIS have a baby?

The sex development of people with AIS means they will not be able to become pregnant or make their partner pregnant.

Do I have PAIS?

People with PAIS may have both male and female physical characteristics. These may include: The urethra being on the underside of the penis, small penis, small scrotum (with a line down the middle or incompletely closed), or undescended testicles. Breast development in males at the time of puberty.

Do people with AIS have a prostate?

The Wolffian ducts don’t respond to the androgens released by the testes, and the ducts either regress or remain in a rudimentary form, but they do not develop into a prostate gland, vas deferens, or seminal vesicles.

Is PAIS male or female?

Partial androgen insensitivity syndrome (PAIS) is genetic condition that affects the sexual development of a male fetus. During pregnancy, male fetuses with PAIS are unable to properly respond to male sex hormones (androgens). As a result, this affects the development of the genitals.

Do people with CAIS have pubic hair?

Pubic hair in the genital and underarm areas is there because of the action of androgen produced in the adrenal glands and the ovaries. People with CAIS usually have either no hair at all in these areas, or very sparse hair.

What is testicular feminization syndrome?

Testicular feminization syndrome: Now more appropriately called the complete androgen insensitivity syndrome, this is a genetic disorder that makes XY fetuses insensitive (unresponsive) to androgens (male hormones). Instead, they are born looking externally like normal girls.

What is testicular feminization (46XY)?

These tests confirmed the suspected diagnosis – testicular feminization (46XY). The pelvic CT scan revealed the lack of uterus and ovaries, hypoplastic vagina, and intra-abdominal prepsoic testes. The testes were removed in order to avoid the malignant risk.

What is the treatment for testicular feminization?

Testicular feminization is a rare disease that must be diagnosed and treated through close work between gynecologists, endocrinologists, geneticians, urologists, and psychiatrists. Bilateral laparoscopic orchiectomy is the best procedure to remove the intra-abdominal testes, in order to avoid their …

What is the meaning of feminization?

1. the normal induction or development of female sex characters. 2. the induction or development of female secondary sex characters in the male, e.g. in testicular sertoli cell tumor. testicular feminization. a condition in which the subject is phenotypically female, but lacks nuclear sex chromatin and is of XY chromosomal sex.