What is cyclosporine induced nephrotoxicity?

Cyclosporine is a potent and useful immunosuppressive agent used primarily in Conjunction with solid organ transplantation. The most serious adverse reaction that limits its use is nephrotoxicity due to effects on the renal vasculature, glomeruli, and tubular function.

What is drug-induced nephropathy?

Drug-induced nephrotoxicity is increasingly recognized as a significant contributor to kidney disease including acute kidney injury (AKI) and chronic kidney disease (CKD). Nephrotoxicity has a wide spectrum, reflecting damage to different nephron segments based upon individual drug mechanisms.

What is cyclosporine toxicity?

High dosages of cyclosporine can cause liver and kidney toxicity. It can also increase someone’s risk of certain types of cancer, especially lymphoma and skin cancer.

What does cyclosporine do to the kidneys?

The cyclosporine group demonstrated reductions in glomerular filtration rate and renal plasma flow, with higher renal vascular resistance and mean arterial pressure as compared with an azathioprine-treated control group.

Can cyclosporine cause kidney problems?

Cyclosporine is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems. It may also decrease the body’s ability to fight infections.

How does cyclosporine cause hyperkalemia?

Extrarenal Effect of Cyclosporine A on Potassium Homeostasis in Renal Transplant Recipients. Cyclosporine A (CyA) is known to cause hyperkalemia by impairing renal potassium excretion.

What is nephropathy?

Nephropathy is the deterioration of kidney function. The final stage of nephropathy is called kidney failure, end-stage renal disease, or ESRD.

What causes nephrotoxicity?

Nephrotoxicity defined as a renal disease or dysfunction, is often caused by drugs, chemicals, industrial, or environmental toxic agents.

Why does cyclosporine cause hyperkalemia?

What is another name for cyclosporine?

Cyclosporine oral capsule is available as a generic drug and as brand-name drugs. Brand names: Gengraf, Neoral, Sandimmune.

Can cyclosporine cause kidney failure?

Cyclosporine is a very strong medicine. It can cause side effects that can be very serious, such as kidney problems.

Can cyclosporine cause renal failure?

Cyclosporine does, however, possess a limited toxic potential to injure renal cortical cells, so that a chronic tubulointerstitial nephropathy may develop with long-term use of this immunosuppressive agent.

Does cyclosporine increase creatinine?

Kidney, Liver, and Heart Transplant: Cyclosporine, the active ingredient of Neoral®, can cause nephrotoxicity and hepatotoxicity when used in high doses. It is not unusual for serum creatinine and BUN levels to be elevated during cyclosporine therapy.

Does cyclosporine cause renal failure?

Cyclosporine-induced acute renal failure, thus, appears to be due predominantly to prerenal, rather than intrarenal, processes in the experimental animal.

What are the causes of nephropathy?

If you’re living with diabetes, factors that can increase your risk of diabetic nephropathy include:

• Uncontrolled high blood sugar (hyperglycemia)
• Uncontrolled high blood pressure (hypertension)
• Being a smoker.
• High blood cholesterol.
• Obesity.
• A family history of diabetes and kidney disease.

How is nephropathy diagnosed?

Kidney biopsy The biopsy needle is inserted through your skin and is often directed using the guidance of an imaging device, such as ultrasound. Diabetic nephropathy is usually diagnosed during routine testing that’s a part of your diabetes management.

What are signs of nephrotoxicity?

If severe enough, nephrotoxicity can show signs of other types of decreased kidney function, such as decreased urination, swelling from fluid retention and high blood pressure. In some patients, nephrotoxicity can also affect other body systems such as the liver or the skin and show signs in those areas as well.

What type of drug is cyclosporine?

Nonribosomal peptideCyclosporine / Classification

What kind of drug is cyclosporine?

Descriptions. Cyclosporine is used together with other medicines to prevent the body from rejecting a transplanted organ (eg, kidney, liver, or heart). It belongs to a group of medicines known as immunosuppressive agents.

What are the long term side effects of cyclosporine?

Side effects include renal toxic effects, hypertension, and an increased risk of malignant neoplasm. The toxicity of cyclosporine is dose-related, yet the safe duration of treatment is undefined.