What does Propionibacterium acnes infect?

Although primarily recognized for its role in acne, P. acnes is an opportunistic pathogen, causing a range of postoperative and device-related infections. These include infections of the bones and joints, mouth, eye and brain.

What causes Propionibacterium acnes?

Cascade of chemicals The airless environment causes the bacterium, Propionibacterium acnes, to turn sebum – an oily matter found in the skin – into fatty acids that activate inflammation in nearby skin cells.

How does Propionibacterium acnes spread?

An under-recognized pathogen Propionibacterium acnes, or P. acnes, live in hair follicles — the tiny pores in our skin from which hairs sprout. When these pores become blocked, the bacteria can multiply and contribute to the inflammation we call acne.

What antibiotic treats Propionibacterium acnes?

Penicillin and cephalosporins are effective against clinical P. acnes infection and biofilm in vitro. Combination antibiotic therapy with rifampin and daptomycin may further increase the clinical efficacy of treatment.

What is the most common disease caused by Propionibacterium?

Affiliations. Propionibacterium acnes is a gram-positive human skin commensal that prefers anaerobic growth conditions and is involved in the pathogenesis of acne (Kirschbaum and Kligman, 1963). Acne is one of the most common skin diseases, affecting more than 45 million individuals in the United States.

What type of bacteria causes acne?

The anaerobic bacterium Propionibacterium acnes is believed to play an important role in the pathophysiology of the common skin disease acne vulgaris.

Where does Propionibacterium come from?

Propionibacterium acnes is a bacterium commonly found on the skin, in pores and hair follicles. These bacteria play an important part in acne. Their role, though, is more positive than was for a long time thought. Propionibacterium acnes is a bacterium commonly found on the skin, in pores and hair follicles.

How do you treat bacterial P acne?

P. acnes is highly susceptible to a wide range of antibiotics, including beta-lactams, quinolones, clindamycin, and rifampin, although resistance to clindamycin is increasing. Treatment requires a combination of surgery and a prolonged antibiotic treatment regimen to successfully eliminate the remaining bacteria.

Where is Propionibacterium acnes most commonly found?

Propionibacterium acnes is the most abundant bacterium on human skin, particularly in sebaceous areas.

What bacterial infection causes acne?

What does Propionibacterium cause?

Propionibacterium acnes is a gram-positive human skin commensal that prefers anaerobic growth conditions and is involved in the pathogenesis of acne (Kirschbaum and Kligman, 1963). Acne is one of the most common skin diseases, affecting more than 45 million individuals in the United States.

Where is Propionibacterium found?

Propionibacterium acnes is a facultative anaerobic Gram-positive bacterium present on human skin as part of the normal flora, as well as in the oral cavity, large intestine, conjunctiva, and external ear canal (1).

What kills Propionibacterium acnes P. acnes?

A number of factors cause acne, but the primary agents are bacteria called Propionibacterium acnes, or PA. Topical treatments containing benzoyl peroxide are commonly used to kill the bacteria.

Where is Propionibacterium acnes found?

While P. acnes is present on all external and internal surfaces (i.e., oral and gastrointestinal epithelia, conjunctiva), it is most prevalent on the human skin. There it resides in hair follicles of the face and back where it is associated with the common skin disease acne vulgaris.

Is acne a virus or bacteria?

A specific species of bacteria, Propionibacterium acnes, is a major cause of the unpleasant, sometimes disfiguring disease doctors call acne vulgaris. The bacteria live inside the pits in the skin that contain hair follicles and sweat glands.

Can bacteriophage formulation control Propionibacterium acnes?

The formulation of bacteriophage in a semi solid preparation for control of Propionibacterium acnesgrowth. PLoS One. 2016;11(3):e0151184.

Does Propionibacterium acnes induce proinflammatory cytokines?

Induction of proinflammatory cytokines by a soluble factor of Propionibacterium acnes: implications for chronic inflammatory acne. Infect Immun. 1995;63(8):3158–3165.

Can mitomycin C induce infectious phages in Propionibacterium acnes?

Recently, similar studies demonstrated that more than 70% of P. acnes could be induced with mitomycin C to generate infectious phages [ 33 R. Lood, M. Mörgelin, A. Holmberg, M. Rasmussen, and M. Collin, “Inducible Siphoviruses in superficial and deep tissue isolates of Propionibacterium acnes ,” BMC Microbiology, vol. 8, article 139, 2008.

When were Propionibacterium acnesbacteriophages first identified?

Propionibacterium acnesBacteriophages Propionibacterium acnesbacteriophages were first identified by Brzin in 1964 [60]. In 1968, Zierdtc et al. isolated phage 174 from Corynebacterium acnesstrains and used it to classify the Corynebacteriumfamily, ultimately finding that 88% of all C. acnesstrains were sensitive to this bacteriophage [54, 61].