What type of extracellular matrix is found in cartilage?
What type of extracellular matrix is found in cartilage?
Cartilage extracellular matrix (ECM) is composed primarily of the network type II collagen (COLII) and an interlocking mesh of fibrous proteins and proteoglycans (PGs), hyaluronic acid (HA), and chondroitin sulfate (CS).
What is the extracellular matrix in bone?
The ECM is a non-cellular three-dimensional structure secreted by cells into the extracellular space. It is composed of specific proteins and polysaccharides.
Does cartilage have extracellular matrix?
Unlike most tissues, articular cartilage does not have blood vessels, nerves, or lymphatics. It is composed of a dense extracellular matrix (ECM) with a sparse distribution of highly specialized cells called chondrocytes.
How do the extracellular matrix of cartilage bone and blood differ?
Bone and cartilage are two specialized forms of connective tissues which are composed of cells embedded within an extracellular matrix….Difference between Bone and Cartilage.
| Bones | Cartilage |
|---|---|
| Presence of blood vessels. | Absence of blood vessels (nutrients are obtained through diffusion) |
Does the extracellular matrix play a role in the pathology of osteoarthritis?
The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis. Biomed Res Int. 2013;2013:1‐10. 10.1155/2013/284873.
What is the composition of cartilage matrix?
Natural, healthy cartilage matrix is mainly composed of collagen type II which provides tensile support for the tissue. Aggrecan, a negatively charged proteoglycan that attracts water molecules, provides the compressive resistant and shock absorbing capability of cartilage under loading [ 2 ].
Is decellularized cartilage chondroinductive for osteochondral tissue engineering?
Sutherland AJ, Beck EC, Dennis SC, et al. Decellularized cartilage may be a chondroinductive material for osteochondral tissue engineering. PLoS One. 2015;10(5):e0121966 10.1371/journal.pone.0121966.
Is extracellular matrix powder a cell carrier for cartilage repair?
Teng Y, Li X, Chen Y, et al. Extracellular matrix powder from cultured cartilage‐like tissue as cell carrier for cartilage repair. J Mater Chem B. 2017;5(18):3283‐3292. 10.1039/C7TB00640C.
