What is the cause of lipemic serum?

The most common cause of lipemia is nonfasting, with recent ingestion of lipid-containing meal. More severe lipemia results from a disease condition causing hypertriglyceridemia (eg, diabetes, genetic hyperlipidemia) or recent intravenous infusion of a lipid emulsion.

What tests are affected by lipemia?

Conclusion: Lipemia causes clinically significant interferences for phosphorus, creatinine, total protein and calcium measurement and those interferences could be effectively removed by ultracentrifugation.

What causes grossly lipemic blood sample?

The most common preanalytical cause of lipemic samples is inadequate time of blood sampling after the meal or parenteral administration of synthetic lipid emulsions.

What is a lipemic blood sample?

Lipemia is defined as visible turbidity in serum or plasma samples due to the presence of lipoprotein particles, especially chylomicrons. The most common cause of turbidity is a high concentration of triglycerides [1,2].

How do you remove lipemia?

Centrifugation. A recommended procedure for treating lipemic samples is centrifugation using ultracentrifuge which effectively removes lipids and allows measurement of large number of analytes (42,43). However, due to the high cost, this equipment it is not available in a large number of laboratories.

Does lipemia affect cholesterol?

These samples were analyzed for total cholesterol (TC) and High Density Lipoprotein-Cholesterol (HDL-C) before and after ultra centrifugation/airfuge. Results: There was a positive correlation between the lipemia and the false high TC and HDL-C.

How does lipemia affect CBC results?

Q: What CBC parameters are affected when the specimen is lipemic? A: Lipemia in a blood specimen used for clinical evaluation can cause significant interference with obtaining accurate test values. Lipemia creates turbidity of a sample and is a result of the accumulation of lipid particles.

What is high lipemia?

Lipemia is a measure of serum transparency. High levels of blood lipids, mostly triglycerides, increase serum turbidity. The lipemia result is expressed in “number of plus signs,” ranging from negative to four pluses (++++).

What does lipemic mean?

: the presence of an excess of fats or lipids in the blood specifically : hypercholesterolemia.

What is the difference between lipemia and hyperlipidemia?

Because cholesterol and triacylglycerols must reside within lipoproteins in plasma, hyperlipidemia is synonymous with hyperlipoproteinemia. Lipemia is a term denoting that hyperlipidemia is severe enough that the plasma looks milky (i.e., lactescent).

Does lipemia affect platelets?

Lipemia has been reported as a source of interference when measuring hemoglobin, white blood cells,4 platelets,5 and even lymphocytes.

What is Hyperapobetalipoproteinemia?

Abstract Hyperapobetalipoproteinemia (hyperapoB) is a common familial lipoprotein disorder associated with premature coronary artery disease (CAD). HyperapoB is characterized by an increased number of small, dense LDL particles.

What are the five types of hyperlipidemia?

There are five types of primary hyperlipoproteinemia:

• Type 1 is an inherited condition.
• Type 2 runs in families.
• Type 3 is a recessively inherited disorder in which intermediate-density lipoproteins (IDL) accumulate in your blood.
• Type 4 is a dominantly inherited disorder.
• Type 5 runs in families.

Does lipemia affect hemoglobin?

A. Lipemia interferes with the accurate determination of hemoglobin, or Hb, by spectroscopy on most hematology analyzers, but it does not generally interfere with determinations (especially impedance based) of red blood cell count, white blood cell count, and platelet count.

Does lipemia affect electrolytes?

Background: Lipemia affects electrolyte concentration obtained by indirect ion selective electrode (ISE) method, but the specific influence on measurements by direct ion selective electrode method is yet to be clearly understood.

How do you reduce lipids in your blood?

The first ways to reduce your lipid levels are (1) eat less fat, (2) exercise regularly and (3) lose weight if you weigh too much. If you smoke, stop smoking. If these steps don’t lower your LDL level enough, your doctor may have you take medicine to take the fat out of your blood.

How serious is hyperlipidemia?

Hyperlipidemia can be very serious if it’s not controlled. As long as high cholesterol is untreated, you’re letting plaque accumulate inside your blood vessels. This can lead to a heart attack or stroke because your blood has a hard time getting through your blood vessels.