What is Aredia used for?

Pamidronate is used to treat high blood calcium levels and certain bone problems (bone metastases/lesions) that may occur with some types of cancer. It is also used to treat a certain type of bone disease (Paget’s disease) that causes abnormal and weak bones.

What drug class is Aredia?

Pamidronate belongs to a class of drugs known as bisphosphonates. It works by slowing the release of calcium from bones to lower blood calcium levels, reducing the risk of broken bones (fractures) and reducing bone pain.

Is Aredia a bisphosphonate?

Aredia is a bisphosphonate. Bisphosphonate medications are used to slow down the osteoclast’s effects on the bone. In doing this it can be useful in slowing down or preventing the complications (bone pain, fractures, or high calcium levels) of the bone breakdown.

How is pamidronate administered?

Pamidronate injection comes as a solution (liquid) to inject into a vein slowly, over 2 to 24 hours. It is usually injected by a health care provider in a doctor’s office, hospital, or clinic.

What are the side effects of zoledronic acid?

More common

• Abdominal or stomach pain.
• back pain.
• bad, unusual, or unpleasant (after) taste.
• bladder pain.
• blistering, crusting, irritation, itching, or reddening of the skin.
• bone pain.
• burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings.
• change in taste.

What is a bone infusion for osteogenesis imperfecta?

Pamidronate strengthens the bone by increasing bone density and corrects the imbalance between bone reabsorption and bone formation which occurs in osteogenesis imperfecta (OI). Pamidronate infusions are most effective when they are given every six weeks in small children and three-monthly in older children.

How do I give Aredia?

Pamidronate is given by a drip (infusion) into a vein. It can usually be given in the outpatient department at the hospital. The infusion may be given over 2 to 4 hours. Your doctor or nurse will tell you how long your treatment will take.

How do you give a pamidronate injection?

How to use Pamidronate DISODIUM Vial. This medication is given by slow injection into a vein for at least 2 hours, but up to 24 hours, or as directed by your doctor. The dosage is based on your medical condition, laboratory tests, and response to treatment.

Who should not take zoledronic acid?

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney problems, dehydration, aspirin-sensitive asthma. Some people using zoledronic acid may have serious jawbone problems. Your doctor should check your mouth before you start this medication.

How long can you take zoledronic acid infusion?

How long to take it. Zoledronic acid is generally prescribed for at least three years, so you need to be happy it is the right option for you. It is recommended that your treatment is formally reviewed by your doctor after three years.

What is the best treatment for osteogenesis imperfecta?

To date, there is no known treatment, medicine, or surgery that will cure osteogenesis imperfecta (OI). The goal of treatment is to prevent deformities and fractures and allow the child to function as independently as possible. Treatments for preventing or correcting symptoms may include: Care of fractures.

What are the side effects of zoledronic acid infusion?

How do you mix an IV pamidronate?

The daily dose must be administered as an intravenous infusion over at least 2 to 24 hours for the 60-mg and 90-mg doses. The recommended dose should be diluted in 1000 mL of sterile 0.45% or 0.9% Sodium Chloride, USP, or 5% Dextrose Injection, USP.

Can pamidronate be given IV push?

The daily dose must be administered as an intravenous infusion over at least 2 hours and up to 24 hours for the 60 mg and 90 mg doses. The recommended dose should be diluted in 1000 mL of sterile 0.45% or 0.9% sodium chloride injection or 5% dextrose injection.

What is IV pamidronate used for?

Pamidronate injection is used to treat hypercalcemia (too much calcium in the blood) that may occur in patients with some types of cancer.

What is the most common side effect of zoledronic acid?

Fever is the most common adverse effect associated with zoledronic acid infusion. Flu-like syndromes including fever, chills, bone pain, and/or arthralgias and myalgias have also occasionally been reported. These symptoms generally did not require treatment and resolved within 24 to 48 hours.

What is the recommended dose of Aredia?

The recommended dose of Aredia in severe hypercalcemia (corrected serum calcium*>13.5 mg/dL) is 90 mg given as a SINGLE-DOSE, intravenous infusion over 2 to 24 hours. Longer infusions (i.e., >2 hours) may reduce the risk for renal toxicity, particularly in patients with preexisting renal insufficiency.

What are the limitations of Aredia for the treatment of renal impairment?

Limited pharmacokinetic data exist in patients with creatinine clearance <30 ml/min (See Clinical Pharmacology, Pharmacokinetics.) For the treatment of bone metastases, the use of Aredia in patients with severe renal impairment is not recommended.

What drugs can Aredia be used to treat?

Aredia has been frequently used with doxorubicin, fluorouracil, cyclophosphamide, methotrexate, mitoxantrone, vinblastine, dexamethasone, prednisone, melphalan, vincristine, megesterol, and tamoxifen.

How long does it take for Aredia to leave your system?

Excretion After administration of 30, 60, and 90 mg of Aredia over 4 hours, and 90 mg of Aredia over 24 hours, an overall mean ± SD of 46 ± 16% of the drug was excreted unchanged in the urine within 120 hours. Cumulative urinary excretion was linearly related to dose. The mean ± SD elimination half-life is 28 ± 7 hours.