What does Pit-1 do?

Prophet of PIT-1 PROP1 is a paired-like transcription factor restricted to the developing anterior pituitary. PROP1 is required for the determination of somatotrophs, lactotrophs, and thyrotrophs and differentiation of gonadotrophs.

What type of gene is pit?

Pit-1 belongs to the larger family of POU-domain DNA binding proteins that are characterized by a unique bi-partite DNA-binding motif consisting of two closely related protein segments that share homology with the superfamily of homeobox regulatory genes.

Which cells have a high level of PIT-1 protein?

Immunocytochemical studies revealed a high expression of Pit-1 protein in the nuclei of only three cell types: somatotropes, lactotropes and thyrotropes.

What is the role of PIT-1 in the pathogenesis of growth hormone?

Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin To date, nine different mutations in the Pit-1 gene resulting in CPHD have been described in mammals. Four of these mutations alter residues important for DNA binding or alter the predicted alpha helical nature of the Pit-1 protein (A158P, R172X, E250X, and W261C).

What is the function of the PIT1 transcription factor?

PIT1 is a pituitary-specific transcription factor responsible for pituitary development and hormone expression in mammals and is a member of the POU family of transcription factors that regulate mammalian development. The POU family is so named because the first 3 members identified were PIT1 and OCT1 (MIM 164175) of mammals,…

How do point mutations in the Pit-1 gene affect its function?

Since Pit-1 has different functions in the somatotroph, lactotroph, and thyrotroph, it is not surprising that point mutations in different regions of the gene interfere in different ways with Pit-1 function. A mutant Pit-1 may be able to carry out its developmental role, but may be aberrant in GH and Prl gene activation or Pit-1 autoregulation.