What does nutritional genomics research tell us about cancer?

Recognition of the interplay between genes and diet could ultimately help identify modifiable molecular targets for preventing, delaying, or reducing the symptoms of cancer and other chronic diseases.

What are the benefits of nutrigenomics?

The expected benefits from nutrigenomics are tremendous and encompass: (1) a better understanding of the toxicity and safety profile of macro- and micronutrients; (2) the prevention of certain diet-associated diseases; (3) the enjoyment of otherwise less healthy food by individuals whose health is not likely to be …

What are the disadvantages of nutrigenomics?

One of the disadvantages of nutrigenomics is costly and time-consuming. Nutrigenomics researches need long-term intervention trials to determine the causal relationship between nutrition and ways of prevention, as well as the outcome of disease which is time-consuming and costly.

How nutrigenomics is useful in treating human diseases?

Thus, Nutrigenomics will help in evaluating the individual nutritional needs based on the genetic profile of the individual (personalized diet) as well as help in curing and preventing the chronic diseases.

What is the role of nutrigenomics in cancer treatment?

Nutrigenomics in cancer: Revisiting the effects of natural compounds Nutrigenomics effects have an important role in the manipulation of dietary components for human benefit, particularly in cancer prevention or treatment.

Can nutrients prevent cancer?

Cancer prevention studies have shown that all of the major signaling pathways de-regulated in different types of cancer, are affected by nutrients. Pathways studied include: carcinogen metabolism, DNA repair, cell proliferation/ apoptosis, differentiation, inflammation, oxidant/antioxidant balance and angiogenesis ( 30 ).

Can altered dietary habits reduce cancer risk?

Alteration of dietary habits is potentially an effective approach for reducing cancer risk.

What role does diet play in the acquisition of malignant phenotypes?

In the acquisition of a malignant phenotype, the diet plays a major role. The integration of all the genomic data, solving the nutrition-genomic puzzle, will support implementing the concept of personalized nutrition ( Fig. 2 ). Fig. 2.