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What does hydroxyurea do for polycythemia vera?

What does hydroxyurea do for polycythemia vera?

Can hydroxyurea help treat polycythemia vera (PV)? Hydroxyurea is a cancer drug that slows down the growth of new cells in your body. In PV, it lowers the number of red blood cells and platelets, which are cells that help blood clot. If you take this drug, you may not need a treatment called phlebotomy.

Does hydroxyurea increase hemoglobin?

Hydroxyurea increases total intracellular hemoglobin (9) in the human K562 erythroleukemia cell line and preferentially increases Gγ-globin mRNA levels in these cells (10).

What are the long-term effects of taking hydroxyurea?

Long-term treatment with hydroxyurea is associated with painful skin ulcers, aphthous ulcers, non-ulcerative toxicity with erythema, and skin infiltration.

What are two conditions that cause polycythemia?

The most common causes of secondary polycythemia include obstructive sleep apnea, obesity hypoventilation syndrome, and chronic obstructive pulmonary disease (COPD). Other causes include testosterone replacement therapy and heavy cigarette smoking.

What are the side effects of hydroxyurea?

Hydroxyurea may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • nausea.
  • vomiting.
  • diarrhea.
  • loss of appetite.
  • weight gain.
  • sores in the mouth and throat.
  • constipation.
  • rash.

Does hydroxyurea lower hemoglobin?

What is hydroxyurea? Hydroxyurea is a medicine you take once a day that can make your sickle cell disease less severe. Taking it regularly can raise your hemoglobin level and lower the number of times you get pain and acute chest syndrome.

Can you take hydroxyurea for life?

Actually, adults with sickle cell disease who take hydroxyurea seem to live longer than those who do not. There is no known limit to how long you can be on the medication so you should take it as long as it is working.

Does hydroxyurea weaken your immune system?

Hydroxyurea can weaken your immune system. Call your doctor at once if you have a fever, chills, body aches, extreme tiredness, shortness of breath, bruising, or unusual bleeding.

What is the most common cause of polycythemia?

Apparent polycythaemia is often caused by being overweight, smoking, drinking too much alcohol or taking certain medicines – including diuretics (tablets for high blood pressure that make you pee more). Apparent polycythaemia may improve if the underlying cause is identified and managed.

What are the two types of polycythemia?

There are two types of polycythemia, which have different causes.

  • Primary polycythemia. Primary polycythemia is also called polycythemia vera (PV).
  • Secondary polycythemia. Secondary polycythemia can occur if the increase in red blood cells is not due to the myeloproliferative disease of PV.
  • Risk factors.

What is the life expectancy of someone with polycythemia vera?

According to an article in Blood Cancer Journal, the median survival time for people with PV is 14 years after diagnosis. The authors take this survival time from a study in which half of the participants were still alive 14 years after diagnosis.

What is the most common side effect of hydroxyurea?

The more common side effects of hydroxyurea can include: stomach pain. constipation. diarrhea.

Why is hydroxyurea hazardous?

Hydroxyurea can temporarily lower the number of white blood cells in your blood which increases the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting.

Is hydroxyurea a chemotherapy?

Hydroxyurea (hydroxycarbamate, Hydrea) is a chemo drug that has helped some patients with CMML live longer. This drug comes as a capsule that’s taken by mouth daily. It can bring the numbers of white blood cells and monocytes down to normal. It may also help shrink an enlarged spleen.

Does hydroxyurea increase life expectancy?

Hydroxyurea reduces some vaso-occlusive complications of SCA. While its mechanism of action is incompletely understood, hydroxyurea is associated with increased levels of HbF in SCA; increased levels of HbF are known to improve survival.

What is difference between polycythemia and polycythemia vera?

Polycythemia, also called erythrocytosis, refers to an increase in red blood cell mass, noted on laboratory evaluation as increased hemoglobin and hematocrit levels. Polycythemia vera is a subtype of polycythemia and is associated with the overproduction of all 3 cell lines.

Is hydroxyurea effective for the treatment of hemoglobin SC in children?

The efficacy of hydroxyurea in hemoglobin SC (HbSC) patients is not well documented. We describe the long-term response to hydroxyurea in children with clinically severe HbSC.

Does hydroxyurea increase hemoglobin and total hemoglobin in sickle cell disease?

We demonstrated that in the course of one year hydroxyurea 10 mg/kg/day can significantly increase HbF, total hemoglobin and RBC indices without any notable side effect in patients with SCD. Keywords: hydroxyurea, sickle cell anemia, hematological improvement

What is hemoglobin SC disease?

Summary Hemoglobin SC disease, is a type of sickle cell disease, which means it affects the shape of the red blood cells. Red blood cells contain a protein called hemoglobin, which is responsible for carrying blood throughout the body.

How is hemoglobin SC disease (scythe) treated?

Treatment of Hemoglobin SC Disease (SCYTHE) If the patient is sexually active, they will be offered birth control. If the patient chooses not to initiate effective birth control, they will be tested at their scheduled vist with a urine pregnancy test. If the patient becomes pregnant they will be removed from the study.

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