What are the side effects of tocotrienols?

However, vitamin E may cause side effects if taken at high doses (400 units or more per day) or for a long period of time. In these situations, nausea, diarrhea, stomach cramps, tiredness, dizziness, blurred vision, and headache may rarely occur.

Can you overdose on tocotrienol?

Scientific research suggests that tocotrienols are generally safe for healthy people to take and there is little risk of overdosing. However, tocotrienols do have anticoagulant properties. So people with certain blood disorders should avoid taking them.

What is the difference between vitamin E and tocotrienols?

The tocopherols are saturated forms of vitamin E, whereas the tocotrienols are unsaturated and possess an isoprenoid side chain. Some evidence suggests that human tissues can convert tocotrienols to tocopherols [2, 3]. Tocopherols consist of a chromanol ring and a 15-carbon tail.

Is gamma-tocopherol healthy?

A form of vitamin E, gamma tocopherol has been shown to have anti-inflammatory and anti-aging properties, as well as protecting against cancer, heart disease and degenerative brain disorders such as Alzheimer’s disease.

What is the role of gamma-tocotrienol in the pathophysiology of radiation poisoning?

Kulkarni SS, Cary LH, Gambles K, Hauer-Jensen M, Kumar KS, Ghosh SP. Gamma-tocotrienol, a radiation prophylaxis agent, induces high levels of granulocyte colony stimulating factor.

What is gamma-tocotrienol?

Gamma-tocotrienol is a tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 7 and 8 and a farnesyl chain at position 2. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite.

Does tocotrienol have anticancer effects?

However, evidence suggested that tocotrienols have anticancer effects and tamoxifen and tocotrienol in vitro demonstrate synergy. Although a 60% lower mortality occurred in the intervention group, this result was not statistically significant.

What is the plasma concentration of tocotrienols?

Tocotrienols are detectable at appreciable levels in the plasma after supplementations. However, there is inadequate data on the plasma concentrations of tocotrienols that are sufficient to demonstrate significant physiological effect and biodistribution studies show their accumulation in vital organs of the body.