What are PPAR-gamma agonists?

PPARγ agonists, such as pioglitazone and rosiglitazone, are insulin-sensitizing drugs used to treat type 2 diabetes mellitus (Yki-Jarvinen, 2004).

What is PPAR-alpha and gamma?

Although PPAR alpha potentiates FA catabolism in the liver and is the molecular target of the lipid-lowering fibrates, PPAR-gamma is essential for adipocyte differentiation and hypertrophy, and mediates the activity of the insulin-sensitizing TZDs.

What are PPAR-alpha agonists?

PPAR-alpha agonists PPARα (alpha) is the main target of fibrate drugs, a class of amphipathic carboxylic acids (clofibrate, gemfibrozil, ciprofibrate, bezafibrate, and fenofibrate). They were originally indicated for cholesterol disorders and more recently for disorders that feature high triglycerides.

What does PPAR-alpha do?

Peroxisome proliferator-activated receptor (PPAR)-alpha is a ligand-activated transcriptional factor that belongs to the family of nuclear receptors. PPAR-alpha regulates the expression of genes involved in fatty acid beta-oxidation and is a major regulator of energy homeostasis.

What does PPAR-gamma do?

PPAR-gamma decreases the inflammatory response of many cardiovascular cells, particularly endothelial cells. PPAR-gamma activates the PON1 gene, increasing synthesis and release of paraoxonase 1 from the liver, reducing atherosclerosis.

What does PPAR gamma do?

What does PPAR alpha do?

What is PPARs function?

PPARs are members of the supergene family of nuclear receptors that function as transcription factors regulating the expression of genes involved in cellular intermediary metabolism and inflammation.

What is a PPAR agonist?

PPAR agonists are drugs which act upon the peroxisome proliferator-activated receptor. They are used for the treatment of symptoms of the metabolic syndrome, mainly for lowering triglycerides and blood sugar . PPAR-alpha and PPAR-gamma are the molecular targets of a number of marketed drugs. The main classes of PPAR agonists are:

What is the best PPAR agonist for diabetes?

The currently available PPAR agonists aimed at diabetes are known as thiazolidinediones or “glitazones.” These include pioglitazone (brand name Actos) and rosiglitazone (Avandia).

What is the role of PPAR in the pathophysiology of asthma?

Animal studies have shown their possible role in amelioration of pulmonary inflammation, especially in asthma. PPARδ (delta) is the main target of a research chemical named GW501516. It has been shown that agonism of PPARδ changes the body’s fuel preference from glucose to lipids.

What is the role of PPAR in adipogenesis?

PPAR-γ is highly expressed in adipocytes and is a major regulator of adipogenesis.14PPAR-γ can activate the expression of phosphoenolpyruvate carboxykinase and glycerol kinase via transcription, which then participate in the production of triglycerides through different pathways.