Is eccrine poroma cancerous?

Summary. Eccrine porocarcinoma is a rare type of skin cancer that may occur by chance or may develop from a benign (non-cancerous) skin tumor. They affect the eccrine sweat glands, which are the major sweat glands of the body.

How is Porocarcinoma treated?

Porocarcinoma is an aggressive skin cancer. Surgery is the main modality of treatment.

What causes Porocarcinoma?

What is the Cause of the Disease? The exact etiology of porocarcinoma is unknown, but like the benign poroma, it is known to arise from the acrosyringium. It is believed to either arise de novo or by malignant degeneration of a longstanding poroma.

What is a eccrine poroma?

Eccrine poroma is a benign tumor which arises from the intraepidermal portion of the eccrine sweat glands. It usually occurs as a solitary lesion in the extremity, with the foot and sole as a common site. It may present as a foot mass, ulcerative lesion, bleeding lesion, or suspected melanoma.

How is eccrine poroma treated?

Excision is typically the treatment of choice, but cryosurgery has also been used successfully [9]. Jo et al. [10] reported a case of imiquimod 5% cream to treat a poroma, resulting in clearance within 4 weeks.

What is metastatic Porocarcinoma?

Abstract. Eccrine porocarcinoma (EPC) is a rare tumor. It develops from the intraepidermal ductal portion of the eccrine sweat gland. Metastatic disease is rare. We report a new case of metastatic eccrine porocarcinoma with a successful management and a good response to docetaxel.

How do you treat poroma?

Treatment for poroma is optional but curative as it is a benign adnexal neoplasm. Deeper lesions may be cured with simple excision, but electrosurgical destruction may be the cure for superficial lesions.

What is the meaning of poroma?

Poroma is a benign adnexal tumor that occurs on the skin and does not affect any other tissue. It shows differentiation toward glandular ductal cells. Its malignant counterpart is known as porocarcinoma, which also shows clear poroid differentiation.

What is eccrine Spiradenoma?

Eccrine spiradenoma is an uncommon benign tumor of skin adnexa originating from eccrine glands, which was first described by Kersting and Helwig [1]. It is usually appeared as a single nodule, but also appears rarely as multiple nodules, and being distributed as a linear form or zosteriform [2].

What is the difference between apocrine and eccrine glands?

Your skin has two types of sweat glands: eccrine and apocrine. Eccrine glands occur over most of your body and open directly onto the surface of your skin. Apocrine glands open into the hair follicle, leading to the surface of the skin.

Are eccrine glands exocrine or endocrine?

Examples of exocrine glands include: Sweat glands: Your sweat glands create and secrete sweat. A type of sweat gland called eccrine sweat glands covers almost your entire body surface.

What causes eccrine Spiradenoma?

Spiradenomas appear to be caused by a defective tumor suppressor gene. A mutation in the CYLD gene on chromosome 9 is found in Brooke-Spiegler syndrome, which features multiple spiradenomas.

Is Spiradenoma malignant?

Malignant eccrine spiradenomas are exceedingly rare tumors. They can arise from a preexisting eccrine spiradenoma or occur as a primary malignant tumor.

What is the main function of the eccrine glands?

Eccrine sweat glands help to maintain homoeostasis, primarily by stabilizing body temperature. Derived from embryonic ectoderm, millions of eccrine glands are distributed across human skin and secrete litres of sweat per day.

How do the functions of eccrine sweat glands and apocrine sweat glands differ?

Apocrine glands are driven by adrenaline and hence, they increase in size during times of stress, sexual stimulation, anxiety, pain and fright. In contrast, the eccrine glands are employed in temperature control and cooling off the body along with excretion of unwanted substances by way of sweat.

What does the eccrine gland secrete?

Eccrine glands also have additional roles in humans. They secrete moisturizing factors such as lactate, urea, sodium and potassium to maintain skin hydration (5). Further, secreted sweat mixed with sebum on the skin surface forms a moisturizing lipid layer (6).

What is eccrine porocarcinoma?

Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm that grows slowly over a long period of time but often experiences an accelerated growth phase. This malignant tumor may arise denovo or evolve from a pre-existing benign eccrine poroma.

What are the surgical options for the treatment of porocarcinoma?

Surgical excision is the treatment of choice. Porocarcinomas have a high risk for lymphatic spread. Cutaneous satellite and lymph node metastases are common. Therefore sentinel lymph node mapping and biopsy are appropriate for the staging of patients with porocarcinoma. Among distal sites of metastasis, the lung is often involved.

What is eccrine poroma and how does it affect the elderly?

Porocarcinoma (malignant eccrine poroma) affects elderly people in their 7th and 8th decade without gender bias. It is typically found on the lower limbs but can also be seen on the trunk, head and neck area and upper extremities. Risk factors include trauma, burning, radiotherapy and potentially also immunosuppression.

What percentage of eccrine tumors are cancer?

Eccrine porocarcinoma (EPC) is a rare malignant cutaneous adnexal tumor1,2. The reported frequency of EPC is 0.005% to 0.01% of all cutaneous tumors, making it the most common malignant eccrine tumor3.