How effective is Taxol and carboplatin for endometrial cancer?

Taxol was delivered at 135 mg/m 2 over 3 hours, and carboplatin was delivery at an area under the curve of 5 over 1 hour. Cycles were repeated every 21 days. Results: The overall response rate was 63% with 28% of patients who had a partial response and 35% of patients who had a complete response.

Why is Taxol given before carboplatin?

by Drugs.com Taxol (paclitaxel, Paxel) must be given before carboplatin because if carboplatin is given before Taxol, it stops Taxol from having an effect on cancer cells.

What are the side effects of Taxol and carboplatin?

Paclitaxel and carboplatin (PC, CarboTaxol)

• Into your bloodstream.
• When to contact your team.
• Increased risk of infection.
• Breathless and looking pale.
• Bruising, bleeding gums and nosebleeds.
• Tiredness and weakness (fatigue) during and after treatment.
• Feeling or being sick.
• Pain in different parts of your body.

What is the success rate of carboplatin?

The 5-year overall survival rates were 66% in cisplatin/vinorelbine group, 55% in carboplatin/vinorelbine group and 70% in cisplatin/vinorelbine/carboplatin/vinorelbine group ( p = 0, 95).

Why is carboplatin given after paclitaxel?

The combination of carboplatin and paclitaxel is widely used to treat multiple solid tumors including ovarian, lung and breast cancer. Usually these drugs are given simultaneously with little regard to the importance of scheduling to obtain a maximal response.

What kind of chemo is used for endometrial cancer?

Chemo drugs used to treat endometrial cancer may include: Paclitaxel (Taxol®) Carboplatin. Doxorubicin (Adriamycin®) or liposomal doxorubicin (Doxil®)

Do you lose your hair with carboplatin?

Your hair may get thinner. But you are unlikely to lose all the hair from your head. Hair loss usually starts after your first or second treatment. It is almost always temporary, and your hair will usually grow back after treatment finishes.

How do you feel after Taxol?

You may feel sick (nausea) although this is usually mild and most people will not actually be sick (vomit). You may start to feel unwell a few hours after your treatment. You’ll be given anti-sickness medication, as tablets or into a vein, before each cycle of chemotherapy.

Will I lose my hair on Taxol?

Your hair may become thin, brittle, or may fall out. This typically begins two to three weeks after treatment starts. This hair loss can be all body hair, including pubic, underarm, legs/arms, eyelashes, and nose hairs. The use of scarves, wigs, hats and hairpieces may help.

Is carboplatin a strong chemo?

In most cases it’s mild and goes away soon after treatment stops, although in some cases it can be permanent. If it’s severe, it may be necessary to reduce the dose of carboplatin or to stop it completely. If you have numbness or tingling, tell your treatment team so they can monitor the symptoms.

Does Taxol and carboplatin cause hair loss?

So, yes, hair loss can be expected with carboplatin and Taxol. But just like with the other side effects, Dr. Boyd says preparation is the key to managing hair loss. Usually, the hair will start to fall out after the second chemo cycle.

How many rounds of carboplatin can you have?

You might have between 4 to 6 cycles. How often you have it depends on your type of cancer. Each treatment takes about an hour.

What is the life expectancy of someone with uterine cancer?

90 out of every 100 (90%) survive their cancer for 1 year or more after they are diagnosed. around 75 out of every 100 (around 75%) will survive their cancer for 5 years or more. more than 70 out of every 100 (more than 70%) will survive their cancer for 10 years or more after diagnosis.

How long does chemo last for uterine cancer?

A cycle of chemotherapy (which is typically 21 or 28 days) refers to the time it takes to give the treatment and then allow the body to recover from the side effects of the medicines. This treatment usually involves a combination of several chemotherapy drugs (called regimens).

Do you gain weight on carboplatin?

Furthermore, paclitaxel-based chemotherapy has been associated with patient weight gain in studies of both breast and lung cancer. Although there has not been a systematic analysis to date, there is some evidence that carboplatin combined with paclitaxel can cause weight gain in ovarian cancer patients.

Do you lose your hair with weekly Taxol?

The drugs paclitaxel (“Taxol”) and docetaxel (“Taxotere “), nearly always cause complete alopecia when given in a third weekly schedule, but hair loss is less frequent when the drugs are given in a weekly schedule. Certain other drugs, like Novantrone, cause hair loss in about 20 per cent of cases.

Do the side effects of Taxol get worse with each treatment?

There is no relationship between the presence or severity of Taxol side effects and the effectiveness of the medication. The Taxol side effects and their severity vary depending on how much of the drug is given, and/or the schedule in which it is given.

How did you feel on Taxol?

How long after Taxol will I feel better?

Many people feel fine for the first few hours following chemotherapy. Usually, some reaction occurs about four to six hours later. However, some people don’t react until 12 or even 24 to 48 hours after treatment. Some people experience almost all of the side effects described below, while others experience almost none.

Will I lose my hair on carboplatin?

What is the goal of Carbo Taxol?

Carboplatin + paclitaxel (also known as Carbo/Taxol) may be given with the goal of cure if the disease is not metastatic (spread to other areas of the body). If the disease is metastatic, it may be given to decrease the symptoms of uterine cancer and prolong life.

What is the PMID for carboplatin and paclitaxel for Advanced endometrial cancer?

PMID: 33078978 Carboplatin and Paclitaxel for Advanced Endometrial Cancer: Final Overall Survival and Adverse Event Analysis of a Phase III Trial (NRG Oncology/GOG0209)

What are the limitations of the paclitaxel-doxorubicin-cisplatin regimen in the treatment of endometrial cancer?

Copyright© 2020 by American Society of Clinical Oncology This article has been cited byother articles in PMC. Abstract PURPOSE Limitations of the paclitaxel-doxorubicin-cisplatin (TAP) regimen in the treatment of endometrial cancer include tolerability and cumbersome scheduling.

Should TCTC be the first-line therapy for Advanced or recurrent endometrial cancer?

TC should be considered the first-line therapy for advanced or recurrent endometrial cancer. The tolerability of the TC regimen further suggests that it should serve as a suitable backbone for combination with targeted therapies in future trials.