How does imatinib cause edema?
How does imatinib cause edema?
Inhibition of PDGF receptor on dermal dendrocytes may be the mechanism reponsible for causing the periorbital edema by imatinib. Imatinib also decreases interstitial fluid pressure and increases the capillary-to-interstitium transport rate in subcutaneous tumors in rats by antagonising PDGF-β.
What causes solid facial edema?
The common differential diagnosis of solid facial edema includes acne, lymphedema of rosacea, Morbihan disease, and Melkersson-Rosenthal syndrome. Some believe that these conditions are identical and are only distinguished based on their etiologies [13, 22].
What is Morbihan disease?
Morbihan disease is a rare condition characterized by chronic and persistent erythematous solid edema localized on the face. It is believed to be a complication of rosacea and may occur at any stage of the disease.
Does rosacea cause edema?
A. Yes, certain rosacea sufferers may experience some swelling (edema) in the face that may become noticeable as early as the initial stage of the disease. The same flushing that brings on rosacea’s progression can be associated with edema, a build-up of fluid in the tissues of the face.
Does Gleevec cause swelling?
In clinical studies of Gleevec, some people had eye-related side effects such as swelling and blurry vision. Eyelid swelling and swelling around the eyes were some of the most common side effects. Up to 74.2% of people who took Gleevec had periorbital edema (swelling of the eye area).
Does Gleevec cause water retention?
Clinical studies of Gleevec included people who took a 400-milligram (mg) dose of the drug. Some common side effects reported in these studies include: fluid retention (excess fluid that causes swelling in your feet, ankles, or legs)
What fluid causes edema?
Edema occurs when tiny blood vessels in your body (capillaries) leak fluid. The fluid builds up in surrounding tissues, leading to swelling.
Does inflammation cause edema?
The swelling process, also known as edema, is the result of acute inflammation, a response triggered by damage to living tissues. In the case of injury, the purpose of the inflammatory response is to remove components of damaged tissue in order to allow the body to begin to heal.
What is rosacea lymphedema?
Morbihan disease, also known as rosacea lymphedema, is a rare and persistent form of lymphedema associated with acne rosacea. 1. It is characterized by a nonpitting and nontender chronic erythematous lymphedema of the forehead, glabella, eyelids, nose, and cheeks.
What is pyoderma faciale?
Rosacea fulminans or pyoderma faciale is a rare cutaneous disorder that usually affects women usually between the ages of 15-46. The disease is characterized by sudden onset of papules, pustules, cysts, and painful coalescing nodules with red-cyanotic centrofacial erythema.
How do you reduce swelling from rosacea?
Gentle daily facial massage may help reduce swelling and inflammation. Use a circular motion with your fingers starting on the central part of the face and work toward the ears. A recent study suggests that caffeine may reduce the risk of developing rosacea. Even so, hot beverages are a common trigger.
What are the most common side effects of Gleevec?
Upset stomach, nausea/vomiting, diarrhea, headache, muscle/joint pain, muscle cramps, dizziness, blurred vision, or drowsiness may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. People using this medication may have serious side effects.
Does imatinib cause leg pain?
Muscle cramps and other neuromuscular or symptoms have been widely reported in patients receiving imatinib. They usually occur in the hands, feet, calves, and thighs, and may be tetanic in nature [2]. The cramps tend not to change over time with respect to pattern, frequency, and severity.
How is intramuscular edema treated?
Support stockings
- Movement. Moving and using the muscles in the part of your body affected by edema, especially your legs, may help pump the excess fluid back toward your heart.
- Elevation.
- Massage.
- Compression.
- Protection.
- Reduce salt intake.
What is peripheral edema?
Leg swelling caused by the retention of fluid in leg tissues is known as peripheral edema. It can be caused by a problem with the venous circulation system, the lymphatic system or the kidneys.
What is the treatment for oedema?
Mild edema usually goes away on its own, particularly if you help things along by raising the affected limb higher than your heart. More-severe edema may be treated with drugs that help your body expel excess fluid in the form of urine (diuretics). One of the most common diuretics is furosemide (Lasix).
Is lymphedema inherited?
In most patients, hereditary lymphedema is inherited in an autosomal dominant manner; however, there is variability in symptoms and severity even within the same family.
How do you treat pyoderma faciale?
What is the treatment for pyoderma faciale?
- Antibiotics.
- Isotretinoin.
- Systemic steroids.
What is peripheral oedema?
What is peripheral oedema? Oedema is an accumulation of interstitial fluid. The volume of fluid in the interstitial space is normally kept constant at around 20% of body weight. Normally leakage from capillaries and lymphatic drainage keep this in balance.
What is follicular perifolliculitis?
Perifolliculitis (see Fig. 6-5C) means accumulation of inflammatory cells around a hair follicle in which the inflammation does not significantly impinge on the follicular epithelium. It can be accompanied by mild follicular spongiosis.
Does peripheral edema cause physical limitations?
This model hypothesizes that peripheral edema can cause pain, leading to physical limitations and decreased activity, which in turn would further increase edema.
What is perifolliculitis capitis abscedens et suffodiens?
In the scalp, the folliculitis can extend to form a dissecting cellulitis: perifolliculitis capitis abscedens et suffodiens. This condition may be seen in association with acne vulgaris or a folliculitis tetrad syndrome of acne conglobata, hidradenitis suppurativa, dissecting cellulitis, and pilonidal cysts.
