Does zonisamide cause loss of appetite?

SIDE EFFECTS: Dizziness, drowsiness, trouble sleeping, lack of coordination, lightheadedness, loss of appetite, diarrhea, and double vision may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

How much weight can you lose on Zonegran?

In the study, published last week in The Journal of the American Medical Association, a team led by Dr. Gadde found that Zonegran caused an average weight loss of about 20 pounds in obese people who took it for eight months. The loss approached 10 percent of body weight.

Do you gain weight on zonisamide?

Longitudinal assessment indicated that zonisamide was associated with a significantly slower rate of BMI and weight increases compared with placebo (P = . 01). No patients in the zonisamide group experienced significant weight gain, compared with 33% of placebo-treated patients (P = . 009).

How fast do you lose weight on zonisamide?

The zonisamide group (n = 19) had a mean weight loss of 9.2 kg (1.7 kg) (9.4% loss) at week 32 compared with 1.5 kg (0.7 kg) (1.8% loss) for the placebo group (n = 17) (t = 4.0; P<. 001). Zonisamide was tolerated well, with few adverse effects.

How long does it take to lose weight on zonisamide?

Zonisamide is an antiepileptic drug that demonstrated weight loss efficacy in obese adults(−5.9 kg vs −0.9 kg) in a 16-week trial with further weight loss in the additional 16-week extension phase.

Does zonisamide speed up metabolism?

Zonisamide does not induce its own metabolism. Plasma clearance of zonisamide is approximately 0.30–0.35 mL/min/kg in patients not receiving enzyme-inducing antiepilepsy drugs (AEDs).

Which is better for weight loss topiramate or zonisamide?

Weight reduction was not statistically different between topiramate or zonisamide. Anticonvulsants were associated with an increase in body mass index, yet the benefits of the two anticonvulsants on weight loss remained despite the counteractive effects of antipsychotics.

Does zonisamide enhance weight loss in obese patients on diet?

We evaluated the efficacy and tolerability of zonisamide, an antiepileptic drug, for enhancing weight loss in obese patients receiving diet and lifestyle guidance. Methods: This was a 1-year, randomized, double-blind, placebo-controlled trial conducted from January 9, 2006, through September 20, 2011, at Duke University Medical Center.

Are there any side effects to taking zonisamide?

Along with its needed effects, zonisamide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking zonisamide:

What is zonisamide used for?

What is Zonisamide? Zonisamide has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 8,161 Zonisamide users for its effectiveness, alternative drugs and more. What is Weight loss? Weight loss is found to be associated with 2,595 drugs and 2,018 conditions by eHealthMe.

How is body mass index calculated for zonisamide?

(Body mass index is calculated as weight in kilograms divided by height in meters squared.) Interventions were daily dosing with placebo (n = 74), 200 mg of zonisamide (n = 76), or 400 mg of zonisamide (n = 75), in addition to diet and lifestyle counseling by a dietitian for 1 year. Primary outcome was change in body weight at 1 year.