What is Pluronic gel?

Pluronic lecithin organogels (PLO gels) are lecithin-based organogels widely used in compounding pharmacies as a vehicle for enhancing the transdermal permeability of many therapeutic drugs.

How do you make Pluronic gel?

Preparation of gel Briefly, F127 (1.8 g) was added to 10 mL PBS (pH 7.4) aqueous solution in flat-bottomed screw-capped glass vials, and gently mixed with magnetic stirrers for 24 hours at 4°C until all of the Pluronic granules were completely dissolved and a clear solution was obtained.

How do you make Pluronic?

1. Dissolve 1 g of Pluronic® F-127 in 10 mL distilled water to make a 10% (w/v) stock solution, or 2 g of Pluronic® F-127 in 10 mL of anhydrous dimethyl sulfoxide (DMSO) to make a 20% (w/v) stock solution. These may require heating from 40 to 50 °C for about 30 minutes. Store solution at room temperature.

Is Pluronic F127 toxic?

Pluronic F-127 (i.e., poloxamer) is water soluble and exhibits low toxicity30. The ability of Pluronic F-127 to solubilize hydrophobic solutes has aroused significant interest for applications in drug delivery and controlled release.

What is pluronic used for?

Consequently, pluronic micelles are effectively used as drug carriers because their assemblies can act as passive drug containers. These assemblies deliver drugs into subcellular compartments by slowly releasing hydrophilic–hydrophobic encapsulated excipients into physiological fluids.

Is pluronic a hydrogel?

Pluronic® F-127 (poloxamer 407) is a synthetic hydrogel made of amphiphilic copolymers consisting of units of ethylene oxide (PEO) and polypropylene oxide (PPO). It is injectable and has a reversible mechanism of gelation [25].

Is pluronic biodegradable?

Moreover, Pluronic F-127 hydrogel has favorable properties such as non-toxicity, biocompatibility, and biodegradability.

Is pluronic a surfactant?

Pluronics (PEO-PPO-PEO or PPO-PEO-PPO), as the first commercially used polymeric surfactants, designed and manufactured by BASF, have been applied in the development of many pharmaceutical formulations and drug load as well as delivery.

Is Pluronic a hydrogel?

Is Pluronic a surfactant?

Is pluronic FDA approved?

Pluronics (PEOx-PPOy-PEOx) are non-ionic triblock copolymers composed of two hydrophilic side chains of poly (ethylene oxide), PEO, and a central hydrophobic chain of poly (propylene oxide), PPO. They are also known as poloxamers and are non-toxic, biodegradable and FDA approved [22].

What are Pluronics® polymers?

Pluronics® or poloxamers are tri-block copolymers of poly (ethylene oxide) poly (propylene oxide)-poly (ethylene oxide) (PEO-PPO-PEO) (Lippens et al., 2013 ). This group of synthetic polymers is thermoreversible in aqueous solutions.

What is the structure of Pluronics?

The hydrophilic ethylene oxide and the hydrophobic propylene oxide give Pluronics an amphiphilic structure – meaning it has a polar, water-soluble group attached to a nonpolar water-insoluble hydrocarbon chain. Amphiphilic block copolymer molecules self-assemble into micelles (a packed chain of molecules) in aqueous solution.

What are the surfactant properties of Pluronics?

Due to their amphiphilic characteristics (presence of hydrophobic and hydrophilic components), pluronics possess surfactant properties which allow them to interact with hydrophobic surfaces and biological membranes ( Batrakova and Kabanov 2008 ).

What are Pluronics used for in chemistry?

Pluronics have also been used successfully as a part of a composition to dissolve blood clots, and to reestablish and maintain the blood flow. R.M. Ottenbrite, R. Javan, in Encyclopedia of Condensed Matter Physics, 2005