What is SERS technique?

Surface enhanced Raman spectroscopy (SERS) is a powerful vibrational spectroscopy technique that allows for highly sensitive structural detection of low concentration analytes through the amplification of electromagnetic fields generated by the excitation of localized surface plasmons.

What is SERS detection?

Among various analytical techniques, surface-enhanced Raman scattering (SERS) is among the most promising methods in detecting trace amounts of molecules owing to its high molecular specificity (i.e., differentiation between different types of molecules) and high sensitivity (i.e., the lowest analyte concentration from …

What is the difference between Raman spectroscopy and SERS?

The normal Raman spectrum for fentanyl contains significantly more peaks than the corresponding SERS spectrum. The SERS bands are also noticeably broader than the normal Raman bands.

What is the SERS effect?

The SERS effect involves the interaction of the metal surface plasmons with the electronic and vibrational states of the adsorbed molecules, under the influence of the oscillating electromagnetic radiation [18].

What is a SERS substrate?

What is a SERS substrate? A Silmeco SERS substrate, called a SERStrate, is essentially a silicon wafer coated with a metal like gold or silver (or a custom metal of choice). The silicon wafer is made up of a special structure – ag/au coated nano-pillars – which facilitates molecular sensing (Raman scattering).

How does surface enhanced Raman work?

Surface-enhanced Raman scattering, or SERS, is a commonly used sensing technique in which inelastic light scattering (Figure 1) by molecules is greatly enhanced (by factors up to 108 or even larger, enabling single-molecule (SM) SERS in some cases) when the molecules are adsorbed onto corrugated metal surfaces such as …

What is SERS effect?

What is SERS physics?

Surface-enhanced Raman spectroscopy or surface-enhanced Raman scattering (SERS) is a surface-sensitive technique that enhances Raman scattering by molecules adsorbed on rough metal surfaces or by nanostructures such as plasmonic-magnetic silica nanotubes.

Why gold and silver are used in SERS?

They are easily oxidised and lose their SERS performances in a few weeks. However, gold nanoparticles have higher stability. For the ease of synthesis, gold nanoparticles are also better. On the other hand, generally silver nanostructures exhibits two-order higher SERS efficiency.

What is Surface Enhanced Resonance Raman Spectroscopy?

Surface-enhanced resonance Raman scattering (SERRS) is a sensitive and selective method for the characterization of sites in biomolecules, which have an electronic transition at energy close to or coincident with the laser frequency used.

What is SERS substrate?

What is silver substrate?

A Silmeco SERS substrate, called a SERStrate, is essentially a silicon wafer coated with a metal like gold or silver (or a custom metal of choice).

What can SERS imaging do for You?

Our work demonstrates super-resolution SERS imaging to probe membrane receptor interactions in cells, providing chemical information and spatial resolution with potential for diverse applications in life science and biomedicine. Publication types Research Support, N.I.H., Extramural

Can SERS imaging guide the surgical excision of tumors?

In particular, the in vivo intraoperative SERS imaging of tumors can delineate the tumor margin, and thus, can guide the surgery of tumor excision 182. The existing SERS imaging speed lags far behind practical needs, mainly limited by Raman signals of SERS nanoprobes.

Are SERS tags the future of intraoperative imaging for cancer treatment?

Therefore, intraoperative imaging guidance that enables more precise delineation of tumor margins, as well as detection of invisible microscopic lesions, is urgently needed in the surgery-based strategies for cancer treatment. Recently, this goal has been facilitated via the use of SERS tags.

What is the best SERS tag for in vivo imaging?

NIR-SERS sensor is promising for SERS tag applied for in vivo imaging with high sensitivity and high penetration depth. Further efforts are expected to develop novel SERS substrates and screen more highly sensitive NIR Raman reporters.