What do you monitor with atypical antipsychotics?

Newer atypical antipsychotics may carry less of a risk of metabolic side effects, but long-term data are lacking. Obtain baseline and periodic monitoring of BMI, waist circumference, HbA1c, fasting plasma glucose, and fasting lipids.

How do antipsychotics affect cholesterol?

Regarding the effects of antipsychotics on cholesterol, antipsychotic treatments have been reported to be associated with increased total and low-density lipoprotein (LDL)-cholesterol as well as decreased HDL-cholesterol [10, 25].

What makes atypical antipsychotics different from one another?

Atypical antipsychotic drugs, by definition, differ from typical antipsychotic agents in producing significantly fewer extrapyramidal symptoms and having a lower risk of tardive dyskinesia in vulnerable clinical populations at doses that produce comparable control of psychosis.

Which antipsychotics cause high cholesterol?

Two antipsychotics in particular (clozapine and olanzapine) had a strong association with increases in body weight, glucose and cholesterol levels. Those drugs with the worst side-effects produced, in only a few weeks, metabolic changes associated with an increased risk of cardiovascular disease of up to 76%.

What are the side effects of atypical antipsychotics?

Common side effects of atypical antipsychotics include:

• Decreased sex drive.
• Weight gain.
• Diabetes.
• High cholesterol.
• Drowsiness.
• Sun sensitivity.
• Diabetes.
• Seizures.

Why do atypical antipsychotics cause metabolic syndrome?

Antipsychotics form the mainstay of treatment for patients with schizophrenia, but many, especially the second-generation antipsychotics, are associated with weight gain, lipid disturbance, and glucose dysregulation, thereby contributing to the development of metabolic syndrome.

What are atypical medications?

The term “atypical” refers to an antipsychotic medication that produces minimal extrapyramidal side effects (EPS) at clinically effective antipsychotic doses, has a low propensity to cause tardive dyskinesia (TD) with long-term treatment, and treats both positive and negative signs and symptoms of schizophrenia [1].

Does haloperidol affect cholesterol?

Haloperidol, a typical antipsychotic, has been shown to inhibit cholesterol biosynthesis by affecting Δ7-reductase, Δ8,7-isomerase, and Δ14-reductase activities, which results in the accumulation of different sterol intermediates.

Why are atypical antipsychotics preferred?

Atypical antipsychotics seem to be preferable than conventional agents in treating psychological symptoms of dementia (BPSD), because they have substantially lower risks of extrapyramidal neurological effects with lower reported rates of parkinsonism and tardive dyskinesia.

Which of the following is an atypical antipsychotic?

Atypical agents currently available include clozapine (Clozaril), risperidone (Risperdal), olanzapine (Zyprexa), quetiapine (Seroquel), ziprasidone (Geodon), aripiprazole (Abilify), and paliperidone (Invega), the active metabolite of risperidone.

What are some of the most common side effect with the new atypical antipsychotics?

Which antipsychotics increase triglycerides?

Clozapine, olanzapine, and quetiapine have been associated with moderate increases in serum triglyceride levels, an early sign of impending metabolic syndrome.

What are side effects of atypical drugs?

Why does quetiapine raise cholesterol?

Quetiapine stimulates NPC1L1 and MTP expression and increases cholesterol uptake in human intestinal cells.

What receptors do atypical antipsychotics block?

Atypical antipsychotics block serotonin 5-HT2 receptors. When the ratio of 5-HT2 to D2 receptor blocking is greater than 1, atypical antipsychotic action such as therapeutic effects on negative symptoms and few EPS are noted.