What is sofosbuvir used for?

Sofosbuvir is used along with ribavirin (Copegus, Rebetol, Ribasphere, others) and sometimes another medication (peginterferon alfa [Pegasys]) to treat certain types of chronic hepatitis C (an ongoing viral infection that damages the liver) in adults.

Who discovered sofosbuvir?

Sofosbuvir is one such compound. It was discovered in 2007 by Michael Sofia at Pharmasset (now part of Gilead Sciences) and approved for use in the United States by the Food and Drug Administration in 2013. The FDA approval was for the combination of sofosbuvir and ribavirin, an antiviral that dates back to 1972.

How did they find a cure for hep C?

The first combo pill with two drugs that inhibits different steps in hepatitis C replication was approved by the FDA in 2014. This pill is taken once a day for 8-12 weeks, has little to no side effects and improved the cure rate to 90-95%.

What is the target of the HCV drug sofosbuvir?

More specifically, Sofosbuvir prevents HCV viral replication by binding to the two Mg2+ ions present in HCV NS5B polymerase’s GDD active site motif and preventing further replication of HCV genetic material 13,Label.

What is the best hep C treatment?

Hepatitis C is treated using direct-acting antiviral (DAA) tablets. DAA tablets are the safest and most effective medicines for treating hepatitis C. They’re highly effective at clearing the infection in more than 90% of people. The tablets are taken for 8 to 12 weeks.

Is sofosbuvir a chain terminator?

Real-time RT-PCR verified that SOF inhibits generation of viral RNA with an EC50 of 9.9 µM. Purified DENV NS5 incorporated the active triphosphate form (SOF-TP) into nascent RNA, causing chain-termination.

Is sofosbuvir generic?

There is currently no generic for Sovaldi (sofosbuvir), so it can be expensive, even with insurance.

Is Sofosbuvir a chain terminator?

Is Sofosbuvir a biologic?

In December of 2013, Sovaldi (sofosbuvir) and Olysio (simeprevir) were approved by the United States Food and Drug Administration. The chemical composition of both Sovaldi and Olysio are different than traditional medications in that they are biologics.

How much does sofosbuvir velpatasvir cost?

The cost for sofosbuvir/velpatasvir oral tablet (400 mg-100 mg) is around $8,170 for a supply of 28, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.

Is Sofosbuvir a DAA?

One of the most potent DAA medications is sofosbuvir, a pan-genotypic nucleotide analogue that inhibits the NS5B polymerase of HCV. Daclatasvir, a pan-genotypic inhibitor of the HCV NS5A replication complex, was recently approved in the United States for treatment of HCV genotype 3 in conjunction with sofosbuvir.

Is sofosbuvir a biologic?