Can cisplatin be given before gemcitabine?

Recently, we described that the schedule in which cisplatin was administered 24 hours before gemcitabine produced the best pharmacological profile. Based on this and because toxicity was manageable, the schedule cisplatin 24 hours prior to gemcitabine was chosen for phase II evaluation.

How long can you take gemcitabine and cisplatin?

You usually have GC chemotherapy as cycles of treatment. Each cycle takes 3 weeks. You usually have between 4 to 6 cycles of treatment taking from 3 to 6 months.

What is gemcitabine plus cisplatin?

Interpretation. Gemcitabine plus cisplatin prolongs progression-free survival in patients with recurrent or metastatic nasopharyngeal carcinoma. The results establish gemcitabine plus cisplatin as the standard first-line treatment option for this population.

How do you give gemcitabine cisplatin?

Every 21-Day Regimen Schedule

1. Gemcitabine I.V. infusion over 30 minutes on Days 1 and 8.
2. Cisplatin I.V. infusion over 1 hour on Day 2 (or Day 1, if recommended by your Doctor)

Is cisplatin a strong chemo?

Presently, cisplatin is one of the most powerful chemotherapeutic drugs used for the treatment of ovarian cancer; even though resistance is typical [20]. In ovarian germ cell cancer, the use of cisplatin brings about high response rates [21].

How effective is gemcitabine?

Since 1997, gemcitabine therapy has been the standard first-line treatment for patients with unresectable locally advanced or metastatic pancreatic cancer. Among patients with metastatic disease, the 5-year survival rate is only 2%,1 and 1-year survival rates of 17 to 23% have been reported with gemcitabine.

How long can you take gemcitabine?

You usually have gemcitabine as a course of several cycles of treatment. This means that you have the drug and then a rest to allow your body to recover. Usually a cycle of gemcitabine is over 3 to 4 weeks (21 to 28 days). You usually have gemcitabine once a week for 2 or 3 weeks and then a week with no treatment.

How long can you stay on gemcitabine?

How long can you take Gemzar?

What is Gemzar used for?

Generic Name: gemcitabine Gemcitabine is used to treat certain types of cancer (including breast, lung, ovarian, pancreatic). It is a chemotherapy drug that works by slowing or stopping the growth of cancer cells.

Does gemcitabine shrink Tumours?

The results presented here suggest that nab-paclitaxel plus gemcitabine effectively reduced primary pancreatic tumor burden even in cases with relatively large tumor burden.

How effective is Gemzar?

Patients taking Abraxane/Gemzar survived 5.5 months before their disease progressed, compared to 3.7 months in patients who took Gemzar alone. The overall response rate (patients who experienced tumor shrinkage) was 23 percent for Abraxane/Gemzar compared with 7 percent for Gemzar alone.

What is gemzar + cisplatin?

Gemcitabine (Gemzar®) + Cisplatin is a Chemotherapy Regimen for Bladder Cancer How does gemcitabine + cisplatin work? Each of the medications in the gemcitabine and cisplatin (also known as gem/cis) regimen are designed to kill or slow growth of bladder cancer cells.

What are the limitations of gemcitabine and cisplatin?

Gemcitabine doses may be reduced or treatment may be delayed for a low platelet count or a low neutrophil count. Cisplatin doses may be reduced or treatment may be delayed nerve pain, hearing loss, or kidney problems.

How often do you give Gemzar and cisplatin?

Gemcitabine (Gemzar) and cisplatin are usually given in an outpatient infusion center, allowing the person to go home afterwards. On occasion, they may be given in the hospital if someone is too sick. Gemcitabine + cisplatin is repeated every 21 or 28 days.

Are cisplatin and gemcitabine effective against lung adenocarcinoma?

A woman in her late 60s [ exact age not stated] exhibited a lack of efficacy to cisplatin and gemcitabine for the treatment of lung adenocarcinoma.