What is Atgam drug?

Atgam is a polyclonal antibody, or an immune globulin, given as an intravenous (IV, into a vein) infusion. Atgam is used to fight a type of white blood cell called a T-lymphocyte (also called a thymocyte or T-cell). T-lymphocytes are part of your immune system.

How long does it take Atgam to work?

If it works, ATG usually stops the need for blood transfusions within 3 months. Full success can take at least 9 months. Some patients may respond initially, but may later relapse and need another treatment.

Is Atgam hazardous?

Inform patients that Atgam may cause serious allergic reactions, infection or abnormal liver or renal function. Advise the patient to discontinue Atgam and seek immediate medical attention if any signs/symptoms of an allergic or immune reaction occur [see Warnings and Precautions (5.1)].

How is Atgam administered?

ATGAM is appropriately administered into a vascular shunt, arterial venous fistula, or a high-flow central vein using an in-line filter with a pore size of 0.2 to 1.0 micron.

Who manufactures Atgam?

ATGAM® (lymphocyte immune globulin, anti-thymocyte globulin [equine] sterile solution)

What is horse ATG?

ATG is a drug made of antibodies that suppress the immune system. It is made by injecting horses with white blood cells from humans, called lymphocytes. By injecting the horses with these human lymphocytes, the horse’s immune system produce antibodies directed against these human lymphocytes.

Is fludarabine a chemotherapy?

Fludarabine is a chemotherapy drug and has the brand name Fludara. Fludarabine is mainly used to treat chronic lymphocytic leukaemia (CLL).

Is cyclosporine A chemotherapy?

Both cyclosporine and prednisolone are immunosuppressive agents commonly used to treat many types of autoimmune diseases. Although they are not typically used in cancer treatment, some thymoma patients have been reported to respond well to prednisolone treatment [10, 11].

Why is paroxetine considered a hazardous drug?

CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. Possible risk of harm to the unborn child. Very toxic to aquatic organisms. Accidental ingestion of the material may be damaging to the health of the individual.

Why is Topamax a hazardous drug?

Topiramate can increase the level of acid in your blood (metabolic acidosis). This can weaken your bones, cause kidney stones, or cause growth problems in children or harm to an unborn baby.

Can ATG be given outpatient?

Atgam® is safe when administered peripherally and should be the route of choice to avoid central line complications. Outpatient administration of Atgam® is safe in many patients and will lead to decreased length of stay.

How much does Antithymocyte globulin cost?

The costs for basiliximab and antithymocyte globulin were calculated based on average wholesale prices (AWP). The price of basiliximab was $1224 per dose and the price of antithymocyte globulin was $262.24 per 250 mg ampoule [9].

How effective is ATG?

Immunosuppression with anti-thymocyte globulin (ATG) was introduced in 1977. Subsequent trials confirmed the effectiveness of this form of treatment. Overall, between 75% and 80% of the patients achieve remission, defined as freedom from transfusion, following a first course of treatment with ATG.

How much does ATG treatment cost?

Table 2

Arm	Mean Dose (mg/kg/day)	Cost/Month ($US)
EPAG	150	30,151
h-ATG	3,366	12,108
Cyclosporine	505	2,013
Cyclosporine (low-dose)	168	796

What class of drug is fludarabine?

Fludarabine injection is used to treat chronic lymphocytic leukemia (CLL; a type of cancer of the white blood cells) in adults who have already been treated with at least one other medication and have not gotten better. Fludarabine injection is in a class of medications called purine analogs.

Does fludarabine cause infertility?

Your fertility, meaning your ability to conceive or father a child, may be affected by fludarabine.

What class of drug is cyclosporine?

Nonribosomal peptideCyclosporine / Classification

Is paroxetine a benzodiazepine?

No. You might experience some of the same side effects while taking alprazolam (Xanax) or paroxetine (Paxil), but the two medications belong to different medication classes. Paroxetine (Paxil) is a selective serotonin reuptake inhibitor (SSRI), while Xanax is a benzodiazepine.

Is Paxil a controlled drug?

Each enteric, film-coated, controlled-release tablet contains paroxetine hydrochloride equivalent to paroxetine as follows: 12.5 mg–yellow, 25 mg–pink, 37.5 mg–blue….Adverse Events Associated With Discontinuation of Treatment: Major Depressive Disorder.

	PAXIL CR (n = 104)	Placebo (n = 109)
Depression	1.9%	0.0%