Why is germinal centers important?

Germinal centers are an important part of the B cell humoral immune response, acting as central factories for the generation of affinity matured B cells specialized in producing improved antibodies that effectively recognize antigen (e.g. infectious agents), and for the production of long-lived plasma cells and durable …

What does GL-9 mean?

GL-9. Qualifying Experience. Or Graduate Education. Or Combination of Experience and Education. Or Superior Academic Achievement (SAA)

What is germinal center lymphoma?

Germinal centers (GC) are transient and dynamic structures that form within lymphoid follicles upon antigen challenge. 1 Antigen‐activated GC B cells undergo rapid proliferation and somatic hypermutation of their immunoglobulin variable genes in order to generate high‐affinity B‐cell receptors (BCR).

What happens in the germinal centre?

The germinal centre (GC) of lymphoid organs is the main structure where antigen-activated B cells diversify their immunoglobulin genes by somatic hypermutation (SHM) to generate high-affinity antibodies.

What is a GL-9 and a GL-7?

GL-9 border patrol agents must fill all the requirements of a GL-7 officer plus develop cases, conduct interviews or interrogations, appear as witnesses in court, analyze and disseminate intelligence information rapidly, use a variety of law enforcement databases and prepare reports.

Where is B220 found?

In reactive lymphoid tissues, B220 is expressed by B cells occupying the mantle zones and by a subpopulation of germinal center cells, but, in contrast, marginal zone B cells in the spleen do not express B220.

What is the gl-7 antibody used for?

The GL-7 antibody has also been reported for use in immunoprecipitation and immunohistochemical staining of frozen tissue sections. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Is the GL7 (T and B cell activation marker) antibody CD22 approved?

This moiety is recognized by CD22. This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt. There are no publications for GL7 (T and B Cell Activation Marker) Antibody (NBP2-00362).

What is the epitope of GL7?

GL7 is commonly used as a marker for mouse germinal center B cells. The epitope of GL7 has been identified as a sialic acid glycan moiety called Neu5Ac. This moiety is recognized by CD22. Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content.

What is the best way to store gl-7 antibody?

The GL-7 antibody has also been reported for use in immunoprecipitation and immunohistochemical staining of frozen tissue sections. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest. Store at 4C.