What class of drug is metaraminol?
What class of drug is metaraminol?
Metaraminol is a member of the class of phenylethanolamines that is 2-amino-1-phenylethanol substituted by a methyl group at position 2 and a phenolic hydroxy group at position 1. A sympathomimetic agent , it is used in the treatment of hypotension.
Does metaraminol increase heart rate?
However, it appears that in truly heroic doses metaraminol actually causes rhythm disturbances, increases the heart rate and increased cardiac contractility.
Is metaraminol a beta blocker?
Metaraminol is a sympathomimetic agent with direct and indirect effects on adrenergic receptors. It has both alpha and beta-adrenergic activity, the former being predominant. Metaraminol increases the force of myocardial contractions as well as having a peripheral vasoconstrictor action.
What is the brand name of metaraminol?
Metaraminol
| Clinical data | |
|---|---|
| Trade names | Aramine, Metaramin, Pressonex |
| AHFS/Drugs.com | International Drug Names |
| License data | US DailyMed: Metaraminol |
| Pregnancy category | AU : C |
Does metaraminol increase blood pressure?
Metaraminol increases the force of myocardial contractions as well as having a peripheral vasoconstrictor action. It increases both systolic and diastolic blood pressures.
When should I take metaraminol?
ARAMINE (metaraminol) is indicated for prevention and treatment of the acute hypotensive state occurring with spinal anesthesia. It is also indicated as adjunctive treatment of hypotension due to hemorrhage, reactions to medications, surgical complications, and shock associated with brain damage due to trauma or tumor.
How quickly does metaraminol work?
Onset of action: 1–2 minutes2 Duration of action: 20–60 minutes2 Half-life: minutes. Metaraminol is the vasoconstrictor of choice for the short-term management of acute hypotension and can be administered by peripheral intravenous catheter.
Does metaraminol cause bradycardia?
Metaraminol: predominantly a direct alpha agonist causing peripheral vasoconstriction. Also has indirect sympathomimetic actions caused by the release of noradrenaline and adrenaline. When used in the treatment of acute hypotension, a baroreceptor mediated bradycardia is frequently seen.
What is normal blood pressure for a 70 year old?
New Blood Pressure Standards for Seniors The ideal blood pressure for seniors is now considered 120/80 (systolic/diastolic), which is the same for younger adults.
What is stroke level BP?
Blood pressure readings above 180/120 mmHg are considered stroke-level, dangerously high, and require immediate medical attention.
How does metaraminol work in the body?
It acts by increasing the force of the heart’s pumping action as well as constricting peripheral blood vessels. Metaraminol acts through peripheral vasoconstriction by acting as a pure alpha-1 adrenergic receptor agonist, consequently increasing systemic blood pressure (both systolic & diastolic).
Is metaraminol a catecholamine analog?
Similar to HED, metaraminol is a catecholamine analog that is resistant to metabolic degradation by MAO and COMT. Metaraminol can be fluorinated without altering the affinity to uptake-1.
Is metaraminol safe for diabetics?
Because of its vasoconstrictor effect ARAMINE (metaraminol) should be given with caution in heart or thyroid disease, hypertension, or diabetes. Sympathomimetic amines may provoke a relapse in patients with a history of malaria. See DRUG INTERACTIONS section.
How do you administer metaraminol?
DOSAGE AND ADMINISTRATION ARAMINE (metaraminol) may be given intramuscularly, subcutaneously, or intravenously, the route depending on the natureand severity of the indication. Parenteraldrug products should be inspected visually for particulate matter and discoloration prior to use, whenever solution and container permit.
