What is RefSeq annotation?

The Reference Sequence (RefSeq) database is an open access, annotated and curated collection of publicly available nucleotide sequences (DNA, RNA) and their protein products. RefSeq was first introduced in 2000.

What is a RefSeq record?

Refseq records are made available in several status levels. Reviewed records represent a compilation of our current knowledge of a gene and its transcripts and protein products. These records, reviewed by NCBI staff scientists or collaborating groups, are analogous to a ‘review article’.

Is RefSeq a database?

NCBI’s reference sequence (RefSeq) database (Author Webpage) is a curated non-redundant collection of sequences representing genomes, transcripts and proteins. The database includes 3774 organisms spanning prokaryotes, eukaryotes and viruses, and has records for 2 879 860 proteins (RefSeq release 19).

What is a RefSeq and why is it important?

The Reference Sequence (RefSeq) collection provides a comprehensive, integrated, non-redundant, well-annotated set of sequences, including genomic DNA, transcripts, and proteins. RefSeq sequences form a foundation for medical, functional, and diversity studies.

What is the difference between RefSeq and GenBank?

Answer. GenBank sequence records are owned by the original submitter and cannot be altered by a third party. RefSeq sequences are not part of the INSDC but are derived from INSDC sequences to provide non-redundant curated data representing our current knowledge of known genes.

How often is RefSeq updated?

The RefSeq Select dataset is refreshed daily as the selection of prokaryote representative genomes is refined and individual genomes are re-annotated. It currently includes about one-third of the prokaryote RefSeq protein dataset.

What RefSeq complete?

A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

How do I download a RefSeq database?

If you were not restricted to RefSeq, you could download such a single faa directly from Uniprot: http://www.uniprot.org/downloads . Use wget to download everything under ftp://ftp.ncbi.nlm.nih.gov/refseq/release// (http://serverfault.com/questions/25199) and using option –accept=LIST to only keep *.

Is RefSeq redundant?

In contrast, RefSeq represents a nearly non-redundant collection that is a synthesis and summary of available information, and represents the ‘current’ view of the sequence information, names and other annotations. RefSeq records can be distinguished from GenBank records by the format of the accession series.

How many genomes are in the RefSeq?

Abstract. The Reference Sequence (RefSeq) project at the National Center for Biotechnology Information (NCBI) contains nearly 200 000 bacterial and archaeal genomes and 150 million proteins with up-to-date annotation.

Can you download the human genome?

The Human Genome data can be downloaded in its entirety, chromosome by chromosome, in segments referred to as “contigs” (for “contiguous sequence”). This data, along with information about the location of genes and other biological features associated with the sequence, is available from NCBI’s public FTP site.

Who has the most Neanderthal DNA today?

East Asians
The amount varies a bit, from less than a percent to likely over 2 percent, depending on our heritage. East Asians seem to have the most Neanderthal DNA in their genomes, followed by those of European ancestry.

What is the most important gene?

Kerpedjiev discovered that the top gene on the list—Tumor protein p53 (TP53)—was mentioned in about 8,500 articles to date, and that it is typically included in about two PubMed papers per day. When he began his research three years ago, TP53 was referenced in about 6,600 articles.

What DNA do we share with bananas?

About 60 percent of our genes have a recognizable counterpart in the banana genome! “Of those 60 percent, the proteins encoded by them are roughly 40 percent identical when we compare the amino acid sequence of the human protein to its equivalent in the banana,” Brody adds.

Which animal has the closest DNA to humans?

chimpanzees
Ever since researchers sequenced the chimp genome in 2005, they have known that humans share about 99% of our DNA with chimpanzees, making them our closest living relatives.

What ethnicity is most Neanderthal?

East Asians seem to have the most Neanderthal DNA in their genomes, followed by those of European ancestry. Africans, long thought to have no Neanderthal DNA, were recently found to have genes from the hominins comprising around 0.3 percent of their genome.

Is there A pretty gene?

“Facial beauty is a human trait that is of great interest worldwide. Previous studies provided evidence that attractiveness is genetically heritable, but no specific genetic variant has been identified for attractiveness”, says Qiongshi Lu, Assistant Professor at UW and principal investigator of the study.

What is the Order of the courts in nm?

NM Courts Supreme Court Court of Appeals First Judicial District Court Second Judicial District Court Third Judicial District Court Fourth Judicial District Court Fifth Judicial District Court Sixth Judicial District Court Seventh Judicial District Court Eighth Judicial District Court Ninth Judicial District Court Tenth Judicial District Court

What records are not included in the RefSeq project?

Not all records in Gene are in scope for the RefSeq project. This includes immunoglobulins, T-cell receptors, most repetitive elements, and records that represent a phenotype only. Lastly, records of an unknown locus type are not provided a curated RefSeq but may be represented with a computationally predicted model.

How do I find a specific RefSeq record?

A RefSeq record is identified easily by inclusion of an underscore in the accession number. Querying Entrez Nucleotide or Protein returns results in the default Summary format that includes a Filter option at the top right to restrict the results to only RefSeq records.

Why do my RefSeq records differ from other reports?

These differences may reflect real sequence variation (polymorphism), or errors or gaps in the available genome sequence. The support for model RefSeq records should be further evaluated by comparing them to other sequence information available in Gene, Related Sequences, and BLAST reports.

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