What is GLA-SE?
What is GLA-SE?
GLA-SE is a safe and potent clinical stage vaccine adjuvant consisting of the synthetic TLR4 agonist glucopyranosyl lipid adjuvant (GLA) formulated in a squalene-in-water emulsion (SE). GLA-SE augments both TH1 and IgG2-skewed antibody responses to a variety of vaccine antigens.
What is GLA adjuvant?
Glucopyranosyl Lipid Adjuvant (GLA) Glucopyranosyl Lipid Adjuvant, a new synthetic lipid A derivative, is composed of a disaccharide backbone, a single phosphate group, and six C14 acyl chains. It is a TLR4 agonist and a highly effective adjuvant that greatly enhances humoral and cellular immune responses.
What is ID93?
ID93 + GLA-SE is a fusion protein TB vaccine candidate combined with the Toll-like Receptor 4 agonist adjuvant, GLA-SE.
What does GLA se stand for?
Methods: The Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant-stable emulsion (GLA-SE) was combined with SVV to stimulate peripheral blood mononuclear cells (PBMCs) in vitro to determine the cytokine response in dendritic cell subsets.
What is ID93 + GLA-se?
Tuberculosis (TB) is the leading cause of infectious death worldwide. Development of improved TB vaccines that boost or replace BCG is a major global health goal. ID93 + GLA-SE is a fusion protein TB vaccine candidate combined with the Toll-like Receptor 4 agonist adjuvant, GLA-SE.
What is the difference between AS04 and GLA se?
The novel adjuvant GLA/SE is comprised of the synthetic TLR4 agonist glucopyranosyl lipid A (GLA) suspended in a stable squalene-based oil-in-water emulsion (SE) [10]. GLA/SE is similar to AS04 in that both are composed of a TLR4 agonist (MPL or GLA) in close association with an adjuvant delivery system (alum or SE).
What is the GLA-se adjuvant?
The most notable of these is the GLA-SE adjuvant which contains a synthetic TLR4 agonist, Glucopyranosyl Lipid Adjuvant (GLA), formulated in a stable nano-emulsion of squalene oil-in-water (SE) [ 1, 2 ]. GLA-SE drives strong T H 1 responses to a variety of antigens that are protective against intracellular infections [ 2 – 7 ].
