What drug interactions are possible with levodopa therapy?

Most frequently checked interactions

• 5-HTP (5-hydroxytryptophan)
• Acetylsalicylic Acid (aspirin)
• Aspirin Low Strength (aspirin)
• Azilect (rasagiline)
• Crestor (rosuvastatin)
• Ginkgo Biloba (ginkgo)
• L-Carnitine (levocarnitine)
• L-Tyrosine (tyrosine)

Which is contraindicated with levodopa?

The use of levodopa is contraindicated with the concurrent use of monoamine oxidase inhibitors (MAOIs) because it can lead to a hypertensive crisis. There should be a 14-day washout period when switching from levodopa to an MAOI or vice versa.

Can carbidopa levodopa be taken with other meds?

Carbidopa has no known severe interactions with other drugs. Carbidopa has no known serious interactions with other drugs.

Which medication should be avoided in patient’s that have Parkinson’s disease?

These drugs include Prochlorperazine (Compazine), Promethazine (Phenergan), and Metoclopramide (Reglan). They should be avoided. Also, drugs that deplete dopamine such as reserpine and tetrabenazine may worsen Parkinson’s disease and parkinsonism and should be avoided in most cases.

What drugs interact with Sinemet?

Some products that may interact with this drug include: antipsychotic drugs (such as chlorpromazine, haloperidol, thioridazine), certain drugs used to treat high blood pressure (such as methyldopa). Taking MAO inhibitors with this medication may cause a serious (possibly fatal) drug interaction.

What supplements should not be taken with carbidopa-levodopa?

Pyridoxine – vitamin B6 With carbidopa in the system, the negative effect of pyridoxine on levodopa does not occur and there is no concern in taking vitamin B6 supplementation. People who are taking levodopa-only should avoid vitamin B6.

Which drug must be given in combination with levodopa and carbidopa?

Plain levodopa produces nausea and vomiting. It is combined with carbidopa to prevent this side effect. The well-known combined carbidopa/levodopa name brand formulation is called Sinemet®. Carbidopa/levodopa remains the most effective drug to treat PD.

What is the most serious adverse reaction associated with the drug levodopa?

General. The most common adverse reactions reported include nausea, dizziness, headache, insomnia, abnormal dreams, dry mouth, dyskinesia, anxiety, constipation, vomiting, and orthostatic hypotension.

What food should be avoided by patients taking levodopa?

If you’re taking a levodopa medication, your doctor may tell you to avoid protein when taking your meds. Both animal and plant protein can interfere with the absorption of levodopa medications. But you should still eat plenty of protein.

What medications should not be taken with carbidopa levodopa?

Avoid taking MAO inhibitors (isocarboxazid, linezolid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, tranylcypromine) during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before treatment with this medication.

What drug is most commonly combined with levodopa and why?

Levodopa is almost always given in combination with the drug carbidopa, which prevents the nausea that can be caused by levodopa alone.

What vitamin is good for Parkinson’s disease?

Scientists have also examined Vitamin E, Vitamin C and health foods to evaluate oxidative properties. Vitamin E can fight damage in the brain caused by free radicals and has been suggested to lower the risk of PD.

What are the long-term side effects of carbidopa levodopa?

Patients receiving long-term levodopa therapy must contend with some adverse effects. After 5 years the majority of these patients suffer fluctuations, dyskinesias, toxicity, or loss of efficacy.

Does milk interfere with carbidopa-levodopa?

These foods may delay gastric emptying, which can decrease and delay the absorption of levodopa. Notes for Consumers: Taking Levodopa with foods with high protein content (like meats, cheeses and other dairy products) may decrease the drug’s absorption into the body. This may reduce the drug’s efficacy for some people.

Can you take vitamins with levodopa?

Vitamin B6 supplementation above 5–10 mg per day reduces the effectiveness of levodopa. However, combining levodopa with carbidopa prevents this adverse effect, so vitamin B6 supplements may safely be taken with Sinemet® (carbidopa/levodopa).