Which organ is targeted in dengue?
Which organ is targeted in dengue?
The liver as a target of immune-mediated mechanisms in dengue fatal cases. The liver is considered as an important target for DENV infection and is the most common organ to be involved in the disease.
What is the target annual CFR for dengue?
The national CFR target for 2016 is <0.9%. CAR has achieved this target in 2014 by attaining a CFR of 0.16%, an 89% lower compared to the national target. It was also a 20% lower compared to 2013 and 47% lower compared to the average 5-year data. In 2015, a total of 8,158 dengue cases were reported as of MW 42 (Fig 2).
What are the four strategy against dengue?
Based on the Department of Health, people need only remind themselves of the 4S Strategy to prevent dengue fever: Search and Destroy, Self-Protection Measures, Seek Early Consultation, and Support Fogging or Spraying.
What kills dengue virus?
To fight the infection, the immune system produces antibodies to neutralize the dengue viral particles, and the complement system is activated to help the antibodies and white blood cells remove the virus. The immune response also includes cytotoxic T cells (lymphocytes), which recognize and kill infected cells.
Why does SGPT and SGOT increase in dengue?
Liver enzyme elevations are common in dengue. Usually the SGOT levels are more than SGPT levels probably due to skeletal muscle injury. Occasionally jaundice is also seen [2].
What is Elisa test for dengue?
What is the test? The dengue MAC-ELISA is used for the qualitative detection of dengue virus IgM antibodies. The MAC-ELISA is based on capturing human IgM antibodies on a microtiter plate using anti-human-IgM antibody followed by the addition of dengue virus antigens.
How do you read a dengue rapid test?
Interpretation of results
- A positive NS1 test result confirms dengue virus infection without providing serotype information.
- A negative NS1 test result does not rule out infection. People with negative NS1 results should be tested for the presence of dengue IgM antibodies to determine possible recent dengue exposure.
What is 4 o’clock habit?
The “4-o’clock habit” seeks to enjoin the communities to take time to weed out dengue breeding sites at 4 p.m. each day. Cleaning before evening is key to reducing the risk of dengue, as mosquitos carrying the disease are most active at dusk.
What is dengue strategy?
The new D.E.N.G.U.E. strategy has been devised by the DOH to educate the public on home treatment of mild dengue cases. This is to also help decongest hospitals by giving an assurance that not all dengue cases require hospital confinement but can be managed at home using the said strategy.
Is CRP high in dengue?
CRP levels in patients with dengue were higher than patients with potential viral infection but lower than patients with potential bacterial infection, resulting in a quadratic association between dengue diagnosis and CRP, with levels of approximately 30 mg/L associated with the highest risk of having dengue.
Why is LFT test done in dengue?
Dengue is spread by the bite of Aedes mosquito. The virus seems to have some hepatotoxic effects. Affliction of liver in form of derangements in the liver function tests is common and may include mild elevations in serum bilirubin, elevated transaminases and derangements in serum albumin.
What is the first stage of dengue?
The most common symptom of dengue is fever with any of the following: Nausea, vomiting. Rash. Aches and pains (eye pain, typically behind the eyes, muscle, joint, or bone pain)
What is IgG IgM and NS1?
Dengue Antigen NS1, IgG and IgM test detects the non-structural protein component (NS1) of the dengue virus and the antibodies (IgG & IgM) produced by the body in response to the infection. NS1 and IgM is secreted into the blood during dengue infection and are detectable within 3-4 days of illness.
What is IgM and IgG in dengue?
Positive IgM and IgG tests for dengue antibodies detected in an initial blood sample mean that it is likely that the person became infected with dengue virus within recent weeks. IgM antibody tests can be positive if a person has been infected with a similar virus, such as chikungunya (called cross-reaction).
How do you address dengue?
Use insect repellent, wear long-sleeved shirts and long pants, and control mosquitoes inside and outside your home. Each year, an estimated 400 million people are infected with dengue virus through the bites of infected mosquitoes.
How can dengue doh be prevented?
The DOH renewed its call to the public to prevent dengue by implementing the enhanced 4-S strategy in their households such as Search and destroy mosquito-breeding sites, Self-protection measures like wearing long pants and long sleeved shirts and daily use of mosquito repellent, Seek early consultation, and Support …
What controls antiviral and apoptotic programs in dengue virus-infected dendritic cells?
Cellular oxidative stress response controls the antiviral and apoptotic programs in dengue virus-infected dendritic cells. PLoS Pathog10:e1004566. doi:10.1371/journal.ppat.1004566. [PMC free article][PubMed] [CrossRef] [Google Scholar] 35.
What are the nonstructural viral proteins used in the pathogenesis of dengue?
Dengue virus, like other members of the Flaviviridaefamily, uses nonstructural viral proteins, such as NS2A, NS4A, NS4B, and NS5, to interfere with or degrade crucial signaling components in order to circumvent the IFN antiviral response.
Is Ade a risk factor for severe dengue disease?
Katzelnick et al. previously reported that a specific range of titer of DENV antibodies in the circulation correlates with risk of severe dengue disease upon a subsequent infection in humans [7]. Consequently, ADE is a cause for concern and challenge in the development and deployment of DENV vaccines.
Can oxidative stress predict severe dengue infection?
Oxidative stress induced changes in plasma protein can be a predictor of imminent severe dengue infection. Acta Trop106:156–161. doi:10.1016/j.actatropica.2008.03.001.
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