What is the Ponticelli regimen?

The Ponticelli regimen is a combination of drug treatments which is used to treat a kidney disease called membranous nephropathy. The Ponticelli regimen is named after Professor Claudio Ponticelli, an Italian doctor, who first demonstrated that it was effective in treating some people with membranous nephropathy.

What is the Ponticelli regimen for membranous nephropathy?

In research studies, people with membranous nephropathy who are treated with the Ponticelli regimen have less protein in their urine at the end of the 6 month treatment. The Ponticelli regimen has been shown to reduce the risk of people developing advanced long-term kidney damage due to the reduction of protein in their urine.

What is the Ponticelli protocol for glomerular disease?

One of the landmark protocols for glomerular disease is the so-called “Ponticelli Protocol”, used in the treatment of idiopathic membranous nephropathy.

Is the cost of rituximab a barrier to widespread use of modified Ponticelli?

Treatment using the modified Ponticelli regimen (mPR) has remained the standard of care for decades, but newer therapies such as rituximab offer promising results with reduced side effects. The cost of this treatment, however, is perceived as a barrier to widespread use, especially in resource limited healthcare systems.

Is Ponticelli regimen effective and safe in achieving remission in non-Hodgkin lymphoma?

Hence, we conclude that Ponticelli regimen is effective and safe in achieving remission in patients with various types of GN, who were resistant to the usual conventional immunosuppressive drugs. To confirm this, a controlled, multicenter trial of this protocol may be needed.

What is the Ponticelli regimen for the treatment of nephrotic syndrome (NS)?

In this study, intravenous MP, Chl, and low-dose prednisolone combination (Ponticelli regimen) was found to be an effective for NS patients resistant to usual immunosuppressive therapy with various types of GN other than membranous nephropathy.